Cargando…
Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Method...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314800/ https://www.ncbi.nlm.nih.gov/pubmed/34336449 http://dx.doi.org/10.7759/cureus.15953 |
_version_ | 1783729608821047296 |
---|---|
author | Mutyala, Monica Ali, Ruhma Chan, Kok Hoe Patel, Aditya Kiwan, Chrystina Ekmekjian, Zareh Koneru, Kalyan Reddy, Dhinesh V Miller, Richard Szabela, Maria Slim, Jihad |
author_facet | Mutyala, Monica Ali, Ruhma Chan, Kok Hoe Patel, Aditya Kiwan, Chrystina Ekmekjian, Zareh Koneru, Kalyan Reddy, Dhinesh V Miller, Richard Szabela, Maria Slim, Jihad |
author_sort | Mutyala, Monica |
collection | PubMed |
description | Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Methods The medical records of adult patients admitted to the hospital with probable COVID-19 were extracted and analyzed. We excluded patients with no serology and no clear outcome at the end of data collection. Patient demographics, medical history, and biochemical and clinical data were retrieved. Results A total of 202 patients were included; 57% were males, the majority were Hispanic (45%), followed by African Americans (22%). Hypertension is the most common comorbidity, followed by diabetes mellitus and chronic kidney disease. We classified them into three groups based on their serology: subacute stage (47 patients) with both immunoglobulin M (IgM) and IgG negative; acute stage (116 patients) with IgM positive and late-stage (39 patients) with IgM negative and IgG positive. We found that elevated lactate dehydrogenase (LDH) and ferritin were present in the IgM+ and IgM-/IgG+ subgroups (p-value of 0.0061 and p-value 0.0013, respectively) while C-reactive protein (CRP) and D-dimer were more elevated in the IgM-/IgG- and IgM+ subgroups (P <0.0001 and p-value of 0.0452, respectively). The IgM+ group had the worst prognosis, with high mortality despite receiving remdesivir and dexamethasone. Conclusion Our findings suggest that the use of serology in patients hospitalized with COVID-19 could predict prognosis; this will need to be validated in a larger prospective study. |
format | Online Article Text |
id | pubmed-8314800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-83148002021-07-29 Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 Mutyala, Monica Ali, Ruhma Chan, Kok Hoe Patel, Aditya Kiwan, Chrystina Ekmekjian, Zareh Koneru, Kalyan Reddy, Dhinesh V Miller, Richard Szabela, Maria Slim, Jihad Cureus Internal Medicine Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Methods The medical records of adult patients admitted to the hospital with probable COVID-19 were extracted and analyzed. We excluded patients with no serology and no clear outcome at the end of data collection. Patient demographics, medical history, and biochemical and clinical data were retrieved. Results A total of 202 patients were included; 57% were males, the majority were Hispanic (45%), followed by African Americans (22%). Hypertension is the most common comorbidity, followed by diabetes mellitus and chronic kidney disease. We classified them into three groups based on their serology: subacute stage (47 patients) with both immunoglobulin M (IgM) and IgG negative; acute stage (116 patients) with IgM positive and late-stage (39 patients) with IgM negative and IgG positive. We found that elevated lactate dehydrogenase (LDH) and ferritin were present in the IgM+ and IgM-/IgG+ subgroups (p-value of 0.0061 and p-value 0.0013, respectively) while C-reactive protein (CRP) and D-dimer were more elevated in the IgM-/IgG- and IgM+ subgroups (P <0.0001 and p-value of 0.0452, respectively). The IgM+ group had the worst prognosis, with high mortality despite receiving remdesivir and dexamethasone. Conclusion Our findings suggest that the use of serology in patients hospitalized with COVID-19 could predict prognosis; this will need to be validated in a larger prospective study. Cureus 2021-06-27 /pmc/articles/PMC8314800/ /pubmed/34336449 http://dx.doi.org/10.7759/cureus.15953 Text en Copyright © 2021, Mutyala et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Mutyala, Monica Ali, Ruhma Chan, Kok Hoe Patel, Aditya Kiwan, Chrystina Ekmekjian, Zareh Koneru, Kalyan Reddy, Dhinesh V Miller, Richard Szabela, Maria Slim, Jihad Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 |
title | Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 |
title_full | Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 |
title_fullStr | Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 |
title_full_unstemmed | Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 |
title_short | Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 |
title_sort | roles and interplay of sars-cov-2 serology with clinical stages of disease in covid-19 |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314800/ https://www.ncbi.nlm.nih.gov/pubmed/34336449 http://dx.doi.org/10.7759/cureus.15953 |
work_keys_str_mv | AT mutyalamonica rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT aliruhma rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT chankokhoe rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT pateladitya rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT kiwanchrystina rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT ekmekjianzareh rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT konerukalyan rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT reddydhineshv rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT millerrichard rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT szabelamaria rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 AT slimjihad rolesandinterplayofsarscov2serologywithclinicalstagesofdiseaseincovid19 |