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Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19

Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Method...

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Autores principales: Mutyala, Monica, Ali, Ruhma, Chan, Kok Hoe, Patel, Aditya, Kiwan, Chrystina, Ekmekjian, Zareh, Koneru, Kalyan, Reddy, Dhinesh V, Miller, Richard, Szabela, Maria, Slim, Jihad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314800/
https://www.ncbi.nlm.nih.gov/pubmed/34336449
http://dx.doi.org/10.7759/cureus.15953
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author Mutyala, Monica
Ali, Ruhma
Chan, Kok Hoe
Patel, Aditya
Kiwan, Chrystina
Ekmekjian, Zareh
Koneru, Kalyan
Reddy, Dhinesh V
Miller, Richard
Szabela, Maria
Slim, Jihad
author_facet Mutyala, Monica
Ali, Ruhma
Chan, Kok Hoe
Patel, Aditya
Kiwan, Chrystina
Ekmekjian, Zareh
Koneru, Kalyan
Reddy, Dhinesh V
Miller, Richard
Szabela, Maria
Slim, Jihad
author_sort Mutyala, Monica
collection PubMed
description Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Methods The medical records of adult patients admitted to the hospital with probable COVID-19 were extracted and analyzed. We excluded patients with no serology and no clear outcome at the end of data collection. Patient demographics, medical history, and biochemical and clinical data were retrieved. Results A total of 202 patients were included; 57% were males, the majority were Hispanic (45%), followed by African Americans (22%). Hypertension is the most common comorbidity, followed by diabetes mellitus and chronic kidney disease. We classified them into three groups based on their serology: subacute stage (47 patients) with both immunoglobulin M (IgM) and IgG negative; acute stage (116 patients) with IgM positive and late-stage (39 patients) with IgM negative and IgG positive. We found that elevated lactate dehydrogenase (LDH) and ferritin were present in the IgM+ and IgM-/IgG+ subgroups (p-value of 0.0061 and p-value 0.0013, respectively) while C-reactive protein (CRP) and D-dimer were more elevated in the IgM-/IgG- and IgM+ subgroups (P <0.0001 and p-value of 0.0452, respectively). The IgM+ group had the worst prognosis, with high mortality despite receiving remdesivir and dexamethasone. Conclusion Our findings suggest that the use of serology in patients hospitalized with COVID-19 could predict prognosis; this will need to be validated in a larger prospective study.
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spelling pubmed-83148002021-07-29 Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19 Mutyala, Monica Ali, Ruhma Chan, Kok Hoe Patel, Aditya Kiwan, Chrystina Ekmekjian, Zareh Koneru, Kalyan Reddy, Dhinesh V Miller, Richard Szabela, Maria Slim, Jihad Cureus Internal Medicine Background Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology is recommended only for seroprevalence. We think it could be useful in differentiating coronavirus disease 2019 (COVID-19) stages, which could in terms of helping improve our therapeutic interventions. Methods The medical records of adult patients admitted to the hospital with probable COVID-19 were extracted and analyzed. We excluded patients with no serology and no clear outcome at the end of data collection. Patient demographics, medical history, and biochemical and clinical data were retrieved. Results A total of 202 patients were included; 57% were males, the majority were Hispanic (45%), followed by African Americans (22%). Hypertension is the most common comorbidity, followed by diabetes mellitus and chronic kidney disease. We classified them into three groups based on their serology: subacute stage (47 patients) with both immunoglobulin M (IgM) and IgG negative; acute stage (116 patients) with IgM positive and late-stage (39 patients) with IgM negative and IgG positive. We found that elevated lactate dehydrogenase (LDH) and ferritin were present in the IgM+ and IgM-/IgG+ subgroups (p-value of 0.0061 and p-value 0.0013, respectively) while C-reactive protein (CRP) and D-dimer were more elevated in the IgM-/IgG- and IgM+ subgroups (P <0.0001 and p-value of 0.0452, respectively). The IgM+ group had the worst prognosis, with high mortality despite receiving remdesivir and dexamethasone. Conclusion Our findings suggest that the use of serology in patients hospitalized with COVID-19 could predict prognosis; this will need to be validated in a larger prospective study. Cureus 2021-06-27 /pmc/articles/PMC8314800/ /pubmed/34336449 http://dx.doi.org/10.7759/cureus.15953 Text en Copyright © 2021, Mutyala et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Mutyala, Monica
Ali, Ruhma
Chan, Kok Hoe
Patel, Aditya
Kiwan, Chrystina
Ekmekjian, Zareh
Koneru, Kalyan
Reddy, Dhinesh V
Miller, Richard
Szabela, Maria
Slim, Jihad
Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
title Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
title_full Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
title_fullStr Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
title_full_unstemmed Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
title_short Roles and Interplay of SARS-CoV-2 Serology With Clinical Stages of Disease in COVID-19
title_sort roles and interplay of sars-cov-2 serology with clinical stages of disease in covid-19
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314800/
https://www.ncbi.nlm.nih.gov/pubmed/34336449
http://dx.doi.org/10.7759/cureus.15953
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