Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonization and growth in the upper respiratory tract. We i...

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Detalles Bibliográficos
Autores principales: Soumana, Illiassou Hamidou, Linz, Bodo, Dewan, Kalyan K., Sarr, Demba, Gestal, Monica C., Howard, Laura K., Caulfield, Amanda D., Rada, Balázs, Harvill, Eric T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314809/
https://www.ncbi.nlm.nih.gov/pubmed/34286682
http://dx.doi.org/10.3201/eid2708.203566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314809/
https://www.ncbi.nlm.nih.gov/pubmed/34286682
http://dx.doi.org/10.3201/eid2708.203566

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