Effects of Patient Characteristics on Diagnostic Performance of Self-Collected Samples for SARS-CoV-2 Testing

We evaluated the performance of self-collected anterior nasal swab (ANS) and saliva samples compared with healthcare worker–collected nasopharyngeal swab specimens used to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used the same PCR diagnostic panel to test all self-co...

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Detalles Bibliográficos
Autores principales: Smith-Jeffcoat, Sarah E., Koh, Mitsuki, Hoffman, Adam, Rebolledo, Paulina A., Schechter, Marcos C., Miller, Halie K., Sleweon, Sadia, Rossetti, Rebecca, Kasinathan, Vyjayanti, Shragai, Talya, O’Laughlin, Kevin, Espinosa, Catherine C., Khalil, George M., Adeyemo, AdeSubomi O., Moorman, Anne, Bauman, Brenda L., Joseph, Kahaliah, O’Hegarty, Michelle, Kamal, Nazia, Atallah, Hany, Moore, Brooks L., Bohannon, Caitlin D., Bankamp, Bettina, Hartloge, Claire, Bowen, Michael D., Paulick, Ashley, Gargis, Amy S., Elkins, Christopher, Stewart, Rebekah J., da Silva, Juliana, Biedron, Caitlin, Tate, Jacqueline E., Wang, Yun F., Kirking, Hannah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314823/
https://www.ncbi.nlm.nih.gov/pubmed/34286681
http://dx.doi.org/10.3201/eid2708.210667
Descripción
Sumario:We evaluated the performance of self-collected anterior nasal swab (ANS) and saliva samples compared with healthcare worker–collected nasopharyngeal swab specimens used to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used the same PCR diagnostic panel to test all self-collected and healthcare worker–collected samples from participants at a public hospital in Atlanta, Georgia, USA. Among 1,076 participants, 51.9% were men, 57.1% were >50 years of age, 81.2% were Black (non-Hispanic), and 74.9% reported >1 chronic medical condition. In total, 8.0% tested positive for SARS-CoV-2. Compared with nasopharyngeal swab samples, ANS samples had a sensitivity of 59% and saliva samples a sensitivity of 68%. Among participants tested 3–7 days after symptom onset, ANS samples had a sensitivity of 80% and saliva samples a sensitivity of 85%. Sensitivity varied by specimen type and patient characteristics. These findings can help physicians interpret PCR results for SARS-CoV-2.

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