Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples

A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in...

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Autores principales: Hagbom, Marie, Lin, Jenny, Falkeborn, Tina, Serrander, Lena, Albert, Jan, Nordgren, Johan, Sharma, Sumit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314841/
https://www.ncbi.nlm.nih.gov/pubmed/34287131
http://dx.doi.org/10.3201/eid2708.210011
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author Hagbom, Marie
Lin, Jenny
Falkeborn, Tina
Serrander, Lena
Albert, Jan
Nordgren, Johan
Sharma, Sumit
author_facet Hagbom, Marie
Lin, Jenny
Falkeborn, Tina
Serrander, Lena
Albert, Jan
Nordgren, Johan
Sharma, Sumit
author_sort Hagbom, Marie
collection PubMed
description A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in genomic equivalents, confirming infectious norovirus.
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spelling pubmed-83148412021-08-07 Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples Hagbom, Marie Lin, Jenny Falkeborn, Tina Serrander, Lena Albert, Jan Nordgren, Johan Sharma, Sumit Emerg Infect Dis Dispatch A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in genomic equivalents, confirming infectious norovirus. Centers for Disease Control and Prevention 2021-08 /pmc/articles/PMC8314841/ /pubmed/34287131 http://dx.doi.org/10.3201/eid2708.210011 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Hagbom, Marie
Lin, Jenny
Falkeborn, Tina
Serrander, Lena
Albert, Jan
Nordgren, Johan
Sharma, Sumit
Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
title Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
title_full Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
title_fullStr Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
title_full_unstemmed Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
title_short Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
title_sort replication in human intestinal enteroids of infectious norovirus from vomit samples
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314841/
https://www.ncbi.nlm.nih.gov/pubmed/34287131
http://dx.doi.org/10.3201/eid2708.210011
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