Generation of fourteen isogenic cell lines for Parkinson’s disease-associated leucine-rich repeat kinase (LRRK2)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with inherited forms of Parkinson’s disease (PD), causing disease by a gain of kinase function. Here, we describe a series of isogenic iPSC lines with any of five pathogenic mutations (N1437H, R1441C, Y1699C, G2019S and I2020T); two hy...

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Detalles Bibliográficos
Autores principales: Beylina, Aleksandra, Langston, Rebekah G., Rosen, Dorien, Reed, Xylena, Cookson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314873/
https://www.ncbi.nlm.nih.gov/pubmed/34087985
http://dx.doi.org/10.1016/j.scr.2021.102354

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