Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model

OBJECTIVES: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid dexamethasone (Dex) on these responses. DESIGN: Bovine...

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Detalles Bibliográficos
Autores principales: Black, Rebecca Mae, Wang, Yang, Struglics, André, Lorenzo, Pilar, Tillgren, Viveka, Rydén, Martin, Grodzinsky, Alan J., Önnerfjord, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315049/
https://www.ncbi.nlm.nih.gov/pubmed/34322675
http://dx.doi.org/10.1016/j.ocarto.2020.100099

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