GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be impeded by tumor resistance mechanisms and normal t...

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Detalles Bibliográficos
Autores principales: Mukha, Anna, Kahya, Uğur, Linge, Annett, Chen, Oleg, Löck, Steffen, Lukiyanchuk, Vasyl, Richter, Susan, Alves, Tiago C., Peitzsch, Mirko, Telychko, Vladyslav, Skvortsov, Sergej, Negro, Giulia, Aschenbrenner, Bertram, Skvortsova, Ira-Ida, Mirtschink, Peter, Lohaus, Fabian, Hölscher, Tobias, Neubauer, Hans, Rivandi, Mahdi, Labitzky, Vera, Lange, Tobias, Franken, André, Behrens, Bianca, Stoecklein, Nikolas H., Toma, Marieta, Sommer, Ulrich, Zschaeck, Sebastian, Rehm, Maximilian, Eisenhofer, Graeme, Schwager, Christian, Abdollahi, Amir, Groeben, Christer, Kunz-Schughart, Leoni A., Baretton, Gustavo B., Baumann, Michael, Krause, Mechthild, Peitzsch, Claudia, Dubrovska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315064/
https://www.ncbi.nlm.nih.gov/pubmed/34335968
http://dx.doi.org/10.7150/thno.58655

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