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Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis
In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315233/ https://www.ncbi.nlm.nih.gov/pubmed/32940644 http://dx.doi.org/10.1093/cid/ciaa1409 |
| _version_ | 1783729686311862272 |
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| author | Leslie, Jhansi L Weddle, Erin Yum, Lauren K Lin, Ye Jenior, Matthew L Lee, Benjamin Ma, Jennie Z Kirkpatrick, Beth D Nayak, Uma Platts-Mills, James A Agaisse, Herve F Haque, Rashidul Petri, William A |
| author_facet | Leslie, Jhansi L Weddle, Erin Yum, Lauren K Lin, Ye Jenior, Matthew L Lee, Benjamin Ma, Jennie Z Kirkpatrick, Beth D Nayak, Uma Platts-Mills, James A Agaisse, Herve F Haque, Rashidul Petri, William A |
| author_sort | Leslie, Jhansi L |
| collection | PubMed |
| description | In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis. |
| format | Online Article Text |
| id | pubmed-8315233 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83152332021-07-28 Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis Leslie, Jhansi L Weddle, Erin Yum, Lauren K Lin, Ye Jenior, Matthew L Lee, Benjamin Ma, Jennie Z Kirkpatrick, Beth D Nayak, Uma Platts-Mills, James A Agaisse, Herve F Haque, Rashidul Petri, William A Clin Infect Dis Online Only Articles In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis. Oxford University Press 2020-09-17 /pmc/articles/PMC8315233/ /pubmed/32940644 http://dx.doi.org/10.1093/cid/ciaa1409 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Online Only Articles Leslie, Jhansi L Weddle, Erin Yum, Lauren K Lin, Ye Jenior, Matthew L Lee, Benjamin Ma, Jennie Z Kirkpatrick, Beth D Nayak, Uma Platts-Mills, James A Agaisse, Herve F Haque, Rashidul Petri, William A Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis |
| title | Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis |
| title_full | Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis |
| title_fullStr | Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis |
| title_full_unstemmed | Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis |
| title_short | Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis |
| title_sort | lewis blood-group antigens are associated with altered susceptibility to shigellosis |
| topic | Online Only Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315233/ https://www.ncbi.nlm.nih.gov/pubmed/32940644 http://dx.doi.org/10.1093/cid/ciaa1409 |
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