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GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()

GlycA is a biomarker of systemic inflammation, quantifying both the protein concentrations and glycosylation states of several acute phase proteins. GlycA has been shown to be associated with both subclinical atherosclerosis and with cardiovascular disease (CVD). GlycA levels are higher in acute and...

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Autores principales: Mehta, Nehal N., Dey, Amit K., Maddineni, Reethika, Kraus, William E., Huffman, Kim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315361/
https://www.ncbi.nlm.nih.gov/pubmed/34327480
http://dx.doi.org/10.1016/j.ajpc.2020.100120
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author Mehta, Nehal N.
Dey, Amit K.
Maddineni, Reethika
Kraus, William E.
Huffman, Kim M.
author_facet Mehta, Nehal N.
Dey, Amit K.
Maddineni, Reethika
Kraus, William E.
Huffman, Kim M.
author_sort Mehta, Nehal N.
collection PubMed
description GlycA is a biomarker of systemic inflammation, quantifying both the protein concentrations and glycosylation states of several acute phase proteins. GlycA has been shown to be associated with both subclinical atherosclerosis and with cardiovascular disease (CVD). GlycA levels are higher in acute and chronic inflammation. During ongoing systemic inflammatory processes, GlycA specific acute phase reactants and proteins undergo circulating concentration and glycosylation pattern changes, and these alterations are reflected in the GlycA NMR signal. Additionally, levels associate with ongoing disease severity in individuals with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and psoriasis thus capturing active inflammation. Furthermore, in these disease states, GlycA is associated with cardiovascular disease (CVD) independent of traditional risk factors including C-reactive protein (CRP). Finally, GlycA levels decrease with exercise, weight loss, and systemic anti-inflammatory agents. Therefore, GlycA appears to be a promising new composite biomarker of active systemic inflammation including assessing CVD risk in patients with inflammatory diseases.
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spelling pubmed-83153612021-07-28 GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases() Mehta, Nehal N. Dey, Amit K. Maddineni, Reethika Kraus, William E. Huffman, Kim M. Am J Prev Cardiol State-of-the-Art Review GlycA is a biomarker of systemic inflammation, quantifying both the protein concentrations and glycosylation states of several acute phase proteins. GlycA has been shown to be associated with both subclinical atherosclerosis and with cardiovascular disease (CVD). GlycA levels are higher in acute and chronic inflammation. During ongoing systemic inflammatory processes, GlycA specific acute phase reactants and proteins undergo circulating concentration and glycosylation pattern changes, and these alterations are reflected in the GlycA NMR signal. Additionally, levels associate with ongoing disease severity in individuals with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and psoriasis thus capturing active inflammation. Furthermore, in these disease states, GlycA is associated with cardiovascular disease (CVD) independent of traditional risk factors including C-reactive protein (CRP). Finally, GlycA levels decrease with exercise, weight loss, and systemic anti-inflammatory agents. Therefore, GlycA appears to be a promising new composite biomarker of active systemic inflammation including assessing CVD risk in patients with inflammatory diseases. Elsevier 2020-11-07 /pmc/articles/PMC8315361/ /pubmed/34327480 http://dx.doi.org/10.1016/j.ajpc.2020.100120 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle State-of-the-Art Review
Mehta, Nehal N.
Dey, Amit K.
Maddineni, Reethika
Kraus, William E.
Huffman, Kim M.
GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
title GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
title_full GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
title_fullStr GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
title_full_unstemmed GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
title_short GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
title_sort glyca measured by nmr spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases()
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315361/
https://www.ncbi.nlm.nih.gov/pubmed/34327480
http://dx.doi.org/10.1016/j.ajpc.2020.100120
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