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Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective
INTRODUCTION: Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease, with significant potential for positive impact on public health and healthcare savings. New clinical practice recommendations are presented in an abridged guidance to...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315409/ https://www.ncbi.nlm.nih.gov/pubmed/34327493 http://dx.doi.org/10.1016/j.ajpc.2021.100151 |
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author | Watts, Gerald F. Sullivan, David R. Hare, David L. Kostner, Karam M. Horton, Ari E. Bell, Damon A. Brett, Tom Trent, Ronald J. Poplawski, Nicola K. Martin, Andrew C. Srinivasan, Shubha Justo, Robert N. Chow, Clara K. Pang, Jing |
author_facet | Watts, Gerald F. Sullivan, David R. Hare, David L. Kostner, Karam M. Horton, Ari E. Bell, Damon A. Brett, Tom Trent, Ronald J. Poplawski, Nicola K. Martin, Andrew C. Srinivasan, Shubha Justo, Robert N. Chow, Clara K. Pang, Jing |
author_sort | Watts, Gerald F. |
collection | PubMed |
description | INTRODUCTION: Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease, with significant potential for positive impact on public health and healthcare savings. New clinical practice recommendations are presented in an abridged guidance to assist practitioners in enhancing the care of all patients with FH. MAIN RECOMMENDATIONS: Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. There is a key role for general practitioners (GPs) working in collaboration with specialists with expertise in lipidology. Advice is given on genetic and cholesterol testing and risk notification of biological relatives undergoing cascade testing for FH; all healthcare professionals should develop skills in genomic medicine. Management is under-pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non-cholesterol risk factors, and appropriate use of low-density lipoprotein (LDL)-cholesterol lowering therapies, including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Recommendations on service design are provided in the full guidance. POTENTIAL IMPACT ON CARE OF FH: These recommendations need to be utilised using judicious clinical judgement and shared decision making with patients and families. Models of care need to be adapted to both local and regional needs and resources. In Australia new government funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of these recommendations. A broad implementation science strategy is, however, required to ensure that the guidance translates into benefit for all families with FH. |
format | Online Article Text |
id | pubmed-8315409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83154092021-07-28 Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective Watts, Gerald F. Sullivan, David R. Hare, David L. Kostner, Karam M. Horton, Ari E. Bell, Damon A. Brett, Tom Trent, Ronald J. Poplawski, Nicola K. Martin, Andrew C. Srinivasan, Shubha Justo, Robert N. Chow, Clara K. Pang, Jing Am J Prev Cardiol Practice Guideline INTRODUCTION: Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease, with significant potential for positive impact on public health and healthcare savings. New clinical practice recommendations are presented in an abridged guidance to assist practitioners in enhancing the care of all patients with FH. MAIN RECOMMENDATIONS: Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. There is a key role for general practitioners (GPs) working in collaboration with specialists with expertise in lipidology. Advice is given on genetic and cholesterol testing and risk notification of biological relatives undergoing cascade testing for FH; all healthcare professionals should develop skills in genomic medicine. Management is under-pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non-cholesterol risk factors, and appropriate use of low-density lipoprotein (LDL)-cholesterol lowering therapies, including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Recommendations on service design are provided in the full guidance. POTENTIAL IMPACT ON CARE OF FH: These recommendations need to be utilised using judicious clinical judgement and shared decision making with patients and families. Models of care need to be adapted to both local and regional needs and resources. In Australia new government funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of these recommendations. A broad implementation science strategy is, however, required to ensure that the guidance translates into benefit for all families with FH. Elsevier 2021-02-04 /pmc/articles/PMC8315409/ /pubmed/34327493 http://dx.doi.org/10.1016/j.ajpc.2021.100151 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Practice Guideline Watts, Gerald F. Sullivan, David R. Hare, David L. Kostner, Karam M. Horton, Ari E. Bell, Damon A. Brett, Tom Trent, Ronald J. Poplawski, Nicola K. Martin, Andrew C. Srinivasan, Shubha Justo, Robert N. Chow, Clara K. Pang, Jing Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective |
title | Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective |
title_full | Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective |
title_fullStr | Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective |
title_full_unstemmed | Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective |
title_short | Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective |
title_sort | synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an australian perspective |
topic | Practice Guideline |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315409/ https://www.ncbi.nlm.nih.gov/pubmed/34327493 http://dx.doi.org/10.1016/j.ajpc.2021.100151 |
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