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Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients

Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting early AMD is not well established in Asian populations as in Western countri...

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Autores principales: Notomi, Shoji, Shiose, Satomi, Ishikawa, Keijiro, Fukuda, Yosuke, Kano, Kumiko, Mori, Kenichiro, Wada, Iori, Kaizu, Yoshihiro, Matsumoto, Hidetaka, Akiyama, Masato, Sonoda, Koh-Hei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315508/
https://www.ncbi.nlm.nih.gov/pubmed/34314466
http://dx.doi.org/10.1371/journal.pone.0255213
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author Notomi, Shoji
Shiose, Satomi
Ishikawa, Keijiro
Fukuda, Yosuke
Kano, Kumiko
Mori, Kenichiro
Wada, Iori
Kaizu, Yoshihiro
Matsumoto, Hidetaka
Akiyama, Masato
Sonoda, Koh-Hei
author_facet Notomi, Shoji
Shiose, Satomi
Ishikawa, Keijiro
Fukuda, Yosuke
Kano, Kumiko
Mori, Kenichiro
Wada, Iori
Kaizu, Yoshihiro
Matsumoto, Hidetaka
Akiyama, Masato
Sonoda, Koh-Hei
author_sort Notomi, Shoji
collection PubMed
description Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting early AMD is not well established in Asian populations as in Western countries. In this study, we retrospectively investigated clinical characteristics and 5-year incidence of neovascular AMD (nAMD) in the fellow eye of unilateral nAMD patients. Of 296 consecutive unilateral nAMD patients who had been followed up more than 5 years, 170 typical AMD, 119 polypoidal choroidal vasculopathy, and 7 retinal angiomatous proliferation were included. To examine factors associated with nAMD occurrence in the fellow eye, drusen and pigmentary abnormality in the fellow eye were classified into 4 categories; Category 1: no or small drusen < 63 μm (37.2%), Category 2: 63–125 μm medium drusen or pigmentary abnormality (22.2%), Category 3: large drusen > 125 μm (25.0%), Category P: pachydrusen (15.5%). The mean sub-foveal choroidal thickness (SFCT) was Category 1: 276 μm, Category 2: 308 μm, Category 3: 246 μm, and Category P: 302 μm, respectively. Of note, SFCT in Category 2 and Category P was significantly larger than those of Category 3. Finally, the 5-year incidence of nAMD in the fellow eye was 32/296 (10.8%); Category 1: 0/110 (0%), Category 2: 12/66 (18.2%), Category 3: 20/74 (27.0%), and Category P: 0/46 (0%). Thus, signs of intermediate AMD (large drusen) as well as those of early AMD, especially the pigmentary abnormality, may contribute to development of bilateral nAMD in Japanese patients.
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spelling pubmed-83155082021-07-31 Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients Notomi, Shoji Shiose, Satomi Ishikawa, Keijiro Fukuda, Yosuke Kano, Kumiko Mori, Kenichiro Wada, Iori Kaizu, Yoshihiro Matsumoto, Hidetaka Akiyama, Masato Sonoda, Koh-Hei PLoS One Research Article Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting early AMD is not well established in Asian populations as in Western countries. In this study, we retrospectively investigated clinical characteristics and 5-year incidence of neovascular AMD (nAMD) in the fellow eye of unilateral nAMD patients. Of 296 consecutive unilateral nAMD patients who had been followed up more than 5 years, 170 typical AMD, 119 polypoidal choroidal vasculopathy, and 7 retinal angiomatous proliferation were included. To examine factors associated with nAMD occurrence in the fellow eye, drusen and pigmentary abnormality in the fellow eye were classified into 4 categories; Category 1: no or small drusen < 63 μm (37.2%), Category 2: 63–125 μm medium drusen or pigmentary abnormality (22.2%), Category 3: large drusen > 125 μm (25.0%), Category P: pachydrusen (15.5%). The mean sub-foveal choroidal thickness (SFCT) was Category 1: 276 μm, Category 2: 308 μm, Category 3: 246 μm, and Category P: 302 μm, respectively. Of note, SFCT in Category 2 and Category P was significantly larger than those of Category 3. Finally, the 5-year incidence of nAMD in the fellow eye was 32/296 (10.8%); Category 1: 0/110 (0%), Category 2: 12/66 (18.2%), Category 3: 20/74 (27.0%), and Category P: 0/46 (0%). Thus, signs of intermediate AMD (large drusen) as well as those of early AMD, especially the pigmentary abnormality, may contribute to development of bilateral nAMD in Japanese patients. Public Library of Science 2021-07-27 /pmc/articles/PMC8315508/ /pubmed/34314466 http://dx.doi.org/10.1371/journal.pone.0255213 Text en © 2021 Notomi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Notomi, Shoji
Shiose, Satomi
Ishikawa, Keijiro
Fukuda, Yosuke
Kano, Kumiko
Mori, Kenichiro
Wada, Iori
Kaizu, Yoshihiro
Matsumoto, Hidetaka
Akiyama, Masato
Sonoda, Koh-Hei
Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
title Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
title_full Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
title_fullStr Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
title_full_unstemmed Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
title_short Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
title_sort drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in japanese patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315508/
https://www.ncbi.nlm.nih.gov/pubmed/34314466
http://dx.doi.org/10.1371/journal.pone.0255213
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