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Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection
We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock–like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)–multibacillary (MB) regimen 2 years before admission. During the cour...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315541/ https://www.ncbi.nlm.nih.gov/pubmed/34314436 http://dx.doi.org/10.1371/journal.pntd.0009453 |
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author | Menaldi, Sri Linuwih Dinakrisma, Anastasia Asylia Thio, Hok Bing Rengganis, Iris Oktaria, Salma |
author_facet | Menaldi, Sri Linuwih Dinakrisma, Anastasia Asylia Thio, Hok Bing Rengganis, Iris Oktaria, Salma |
author_sort | Menaldi, Sri Linuwih |
collection | PubMed |
description | We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock–like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)–multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Helminth infection was subsequently revealed by endoscopic examination followed by parasitological culture. Resolution of symptoms and normal level of organ function–specific markers were resolved within 3 days following anthelmintic treatment. This report demonstrated the challenge in the diagnosis and treatment of severe T2R. Given that helminth infections may trigger severe T2R that mimics septic shock, health professionals need to be aware of this clinical presentation, especially in endemic regions of both diseases. |
format | Online Article Text |
id | pubmed-8315541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83155412021-07-31 Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection Menaldi, Sri Linuwih Dinakrisma, Anastasia Asylia Thio, Hok Bing Rengganis, Iris Oktaria, Salma PLoS Negl Trop Dis Symposium We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock–like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MDT)–multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Helminth infection was subsequently revealed by endoscopic examination followed by parasitological culture. Resolution of symptoms and normal level of organ function–specific markers were resolved within 3 days following anthelmintic treatment. This report demonstrated the challenge in the diagnosis and treatment of severe T2R. Given that helminth infections may trigger severe T2R that mimics septic shock, health professionals need to be aware of this clinical presentation, especially in endemic regions of both diseases. Public Library of Science 2021-07-27 /pmc/articles/PMC8315541/ /pubmed/34314436 http://dx.doi.org/10.1371/journal.pntd.0009453 Text en © 2021 Menaldi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Symposium Menaldi, Sri Linuwih Dinakrisma, Anastasia Asylia Thio, Hok Bing Rengganis, Iris Oktaria, Salma Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
title | Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
title_full | Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
title_fullStr | Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
title_full_unstemmed | Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
title_short | Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
title_sort | unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
topic | Symposium |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315541/ https://www.ncbi.nlm.nih.gov/pubmed/34314436 http://dx.doi.org/10.1371/journal.pntd.0009453 |
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