The Role of lncRNA PCAT6 in Cancers

Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Siying, Chen, Zhenyao, Gu, Jingyao, Chen, Xin, Wang, Zhaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315724/
https://www.ncbi.nlm.nih.gov/pubmed/34327141
http://dx.doi.org/10.3389/fonc.2021.701495
_version_ 1783729760085475328
author Wang, Siying
Chen, Zhenyao
Gu, Jingyao
Chen, Xin
Wang, Zhaoxia
author_facet Wang, Siying
Chen, Zhenyao
Gu, Jingyao
Chen, Xin
Wang, Zhaoxia
author_sort Wang, Siying
collection PubMed
description Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion, and nervous systems. PCAT6 was found to be highly expressed in gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, bladder cancer, ovarian cancer, breast cancer, cervical cancer, osteosarcoma, glioblastoma, and other tumors. PCAT6 can promote the development and progression of different types of malignant tumors through various mechanisms. Overall, these findings suggest that PCAT6 may play an increasingly vital role in the clinical assessment of these malignant tumors. It can function as an oncogene and may be used as a potential new prognostic biomarker of these tumors.
format Online
Article
Text
id pubmed-8315724
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83157242021-07-28 The Role of lncRNA PCAT6 in Cancers Wang, Siying Chen, Zhenyao Gu, Jingyao Chen, Xin Wang, Zhaoxia Front Oncol Oncology Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion, and nervous systems. PCAT6 was found to be highly expressed in gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, bladder cancer, ovarian cancer, breast cancer, cervical cancer, osteosarcoma, glioblastoma, and other tumors. PCAT6 can promote the development and progression of different types of malignant tumors through various mechanisms. Overall, these findings suggest that PCAT6 may play an increasingly vital role in the clinical assessment of these malignant tumors. It can function as an oncogene and may be used as a potential new prognostic biomarker of these tumors. Frontiers Media S.A. 2021-07-13 /pmc/articles/PMC8315724/ /pubmed/34327141 http://dx.doi.org/10.3389/fonc.2021.701495 Text en Copyright © 2021 Wang, Chen, Gu, Chen and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Siying
Chen, Zhenyao
Gu, Jingyao
Chen, Xin
Wang, Zhaoxia
The Role of lncRNA PCAT6 in Cancers
title The Role of lncRNA PCAT6 in Cancers
title_full The Role of lncRNA PCAT6 in Cancers
title_fullStr The Role of lncRNA PCAT6 in Cancers
title_full_unstemmed The Role of lncRNA PCAT6 in Cancers
title_short The Role of lncRNA PCAT6 in Cancers
title_sort role of lncrna pcat6 in cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315724/
https://www.ncbi.nlm.nih.gov/pubmed/34327141
http://dx.doi.org/10.3389/fonc.2021.701495
work_keys_str_mv AT wangsiying theroleoflncrnapcat6incancers
AT chenzhenyao theroleoflncrnapcat6incancers
AT gujingyao theroleoflncrnapcat6incancers
AT chenxin theroleoflncrnapcat6incancers
AT wangzhaoxia theroleoflncrnapcat6incancers
AT wangsiying roleoflncrnapcat6incancers
AT chenzhenyao roleoflncrnapcat6incancers
AT gujingyao roleoflncrnapcat6incancers
AT chenxin roleoflncrnapcat6incancers
AT wangzhaoxia roleoflncrnapcat6incancers