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PERK-Dependent Activation of the JAK2/STAT3 Pathway Contributes to High Glucose-Induced Extracellular Matrix Deposition in Renal Tubular Epithelial Cells

BACKGROUND: Although the deposition of extracellular matrix (ECM) is critical leading to tubular damage in diabetic kidney disease (DKD), the mechanism still remains unclear. The purpose of this study was to demonstrate a role for protein kinase R-like endoplasmic reticulum kinase (PERK) (a protein...

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Detalles Bibliográficos
Autores principales:	Bao, Yan, Liang, Wei, Ye, Yingchun, Yi, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315854/ https://www.ncbi.nlm.nih.gov/pubmed/34335747 http://dx.doi.org/10.1155/2021/8475868

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