Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests

Xpert MTB/RIF rapidly detects resistance to rifampicin (RR); however, this test misses I491F-RR conferring rpoB mutation, common in southern Africa. In addition, Xpert MTB/RIF does not distinguish between viable and dead Mycobacterium tuberculosis (MTB). We aimed to investigate the ability of thin-l...

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Detalles Bibliográficos
Autores principales: Ardizzoni, E., Ariza, E., Mulengwa, D., Mpala, Q., de La Tour, R., Maphalala, G., Varaine, F., Kerschberger, B., Graulus, P., Page, A. L., Niemann, S., Dreyer, V., Van Deun, A., Decroo, T., Rigouts, L., de Jong, B. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315964/
https://www.ncbi.nlm.nih.gov/pubmed/33722892
http://dx.doi.org/10.1128/AAC.02263-20

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