Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect

Pharmacological activation of the glycolytic enzyme PKM2 or expression of the constitutively active PKM1 isoform in cancer cells results in decreased lactate production, a phenomenon known as the PKM2 paradox in the Warburg Effect. Here we show that oxaloacetate (OAA) is a competitive inhibitor of h...

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Detalles Bibliográficos
Autores principales: Wiese, Elizabeth K., Hitosugi, Sadae, Loa, Sharon T., Sreedhar, Annapoorna, Andres-Beck, Lindsey G., Kurmi, Kiran, Pang, Yuan-Ping, Karnitz, Larry M., Gonsalves, Wilson I., Hitosugi, Taro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316326/
https://www.ncbi.nlm.nih.gov/pubmed/34226744
http://dx.doi.org/10.1038/s42255-021-00424-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316326/
https://www.ncbi.nlm.nih.gov/pubmed/34226744
http://dx.doi.org/10.1038/s42255-021-00424-5

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