TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells

Tribbles homolog 2 (TRIB2) is known to boost liver tumorigenesis via regulating Ubiquitin (Ub) proteasome system (UPS). At least two ways are involved, i.e., acts as an adaptor protein to modulate ubiquitination functions of certain ubiquitin E3 ligases (E3s) and reduces global Ub levels via increas...

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Detalles Bibliográficos
Autores principales: Guo, Susu, Chen, Yuxin, Xue, Xiangfei, Yang, Yueyue, Wang, Yikun, Qiu, Shiyu, Cui, Jiangtao, Zhang, Xiao, Ma, Lifang, Qiao, Yongxia, Wang, Jiayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316344/
https://www.ncbi.nlm.nih.gov/pubmed/34315867
http://dx.doi.org/10.1038/s41420-021-00574-1

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