Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.

Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling and metabolically leverages iron are poorly understood. We demonstrate that the liver-derived, endocrine regulator of systemic iron balance, hepcidin, is activated ectopically...

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Detalles Bibliográficos
Autores principales: Schwartz, Andrew J., Goyert, Joshua W., Solanki, Sumeet, Kerk, Samuel A., Chen, Brandon, Castillo, Cristina, Hsu, Peggy P., Do, Brian T., Singhal, Rashi, Dame, Michael K., Lee, Ho-Joon, Spence, Jason R., Lakhal-Littleton, Samira, Vander Heiden, Matthew G., Lyssiotis, Costas A., Xue, Xiang, Shah, Yatrik M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316354/
https://www.ncbi.nlm.nih.gov/pubmed/34155415
http://dx.doi.org/10.1038/s42255-021-00406-7

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