Lowering DNA binding affinity of SssI DNA methyltransferase does not enhance the specificity of targeted DNA methylation in E. coli

Targeted DNA methylation is a technique that aims to methylate cytosines in selected genomic loci. In the most widely used approach a CG-specific DNA methyltransferase (MTase) is fused to a sequence specific DNA binding protein, which binds in the vicinity of the targeted CG site(s). Although the te...

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Detalles Bibliográficos
Autores principales: Ślaska-Kiss, Krystyna, Zsibrita, Nikolett, Koncz, Mihály, Albert, Pál, Csábrádi, Ákos, Szentes, Sarolta, Kiss, Antal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316445/
https://www.ncbi.nlm.nih.gov/pubmed/34315949
http://dx.doi.org/10.1038/s41598-021-94528-3

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