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NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we demonstrate that never in mitosis gene A-related kinase 2 (NEK2) phosphorylates PD-L1 to main...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiaozhen, Huang, Xing, Xu, Jian, Li, Enliang, Lao, Mengyi, Tang, Tianyu, Zhang, Gang, Guo, Chengxiang, Zhang, Xiaoyu, Chen, Wen, Yadav, Dipesh Kumar, Bai, Xueli, Liang, Tingbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316469/ https://www.ncbi.nlm.nih.gov/pubmed/34315872 http://dx.doi.org/10.1038/s41467-021-24769-3

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