Cargando…
The trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316550/ https://www.ncbi.nlm.nih.gov/pubmed/34315889 http://dx.doi.org/10.1038/s41467-021-24482-1 |
| _version_ | 1783729873920983040 |
|---|---|
| author | Wu, Peng Chen, Dongsheng Ding, Wencheng Wu, Ping Hou, Hongyan Bai, Yong Zhou, Yuwen Li, Kezhen Xiang, Shunian Liu, Panhong Ju, Jia Guo, Ensong Liu, Jia Yang, Bin Fan, Junpeng He, Liang Sun, Ziyong Feng, Ling Wang, Jian Wu, Tangchun Wang, Hao Cheng, Jin Xing, Hui Meng, Yifan Li, Yongsheng Zhang, Yuanliang Luo, Hongbo Xie, Gang Lan, Xianmei Tao, Ye Li, Jiafeng Yuan, Hao Huang, Kang Sun, Wan Qian, Xiaobo Li, Zhichao Huang, Mingxi Ding, Peiwen Wang, Haoyu Qiu, Jiaying Wang, Feiyue Wang, Shiyou Zhu, Jiacheng Ding, Xiangning Chai, Chaochao Liang, Langchao Wang, Xiaoling Luo, Lihua Sun, Yuzhe Yang, Ying Zhuang, Zhenkun Li, Tao Tian, Lei Zhang, Shaoqiao Zhu, Linnan Chang, Ashley Chen, Lei Wu, Yiquan Ma, Xiaoyan Chen, Fang Ren, Yan Xu, Xun Liu, Siqi Wang, Jian Yang, Huanming Wang, Lin Sun, Chaoyang Ma, Ding Jin, Xin Chen, Gang |
| author_facet | Wu, Peng Chen, Dongsheng Ding, Wencheng Wu, Ping Hou, Hongyan Bai, Yong Zhou, Yuwen Li, Kezhen Xiang, Shunian Liu, Panhong Ju, Jia Guo, Ensong Liu, Jia Yang, Bin Fan, Junpeng He, Liang Sun, Ziyong Feng, Ling Wang, Jian Wu, Tangchun Wang, Hao Cheng, Jin Xing, Hui Meng, Yifan Li, Yongsheng Zhang, Yuanliang Luo, Hongbo Xie, Gang Lan, Xianmei Tao, Ye Li, Jiafeng Yuan, Hao Huang, Kang Sun, Wan Qian, Xiaobo Li, Zhichao Huang, Mingxi Ding, Peiwen Wang, Haoyu Qiu, Jiaying Wang, Feiyue Wang, Shiyou Zhu, Jiacheng Ding, Xiangning Chai, Chaochao Liang, Langchao Wang, Xiaoling Luo, Lihua Sun, Yuzhe Yang, Ying Zhuang, Zhenkun Li, Tao Tian, Lei Zhang, Shaoqiao Zhu, Linnan Chang, Ashley Chen, Lei Wu, Yiquan Ma, Xiaoyan Chen, Fang Ren, Yan Xu, Xun Liu, Siqi Wang, Jian Yang, Huanming Wang, Lin Sun, Chaoyang Ma, Ding Jin, Xin Chen, Gang |
| author_sort | Wu, Peng |
| collection | PubMed |
| description | The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19. |
| format | Online Article Text |
| id | pubmed-8316550 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83165502021-08-03 The trans-omics landscape of COVID-19 Wu, Peng Chen, Dongsheng Ding, Wencheng Wu, Ping Hou, Hongyan Bai, Yong Zhou, Yuwen Li, Kezhen Xiang, Shunian Liu, Panhong Ju, Jia Guo, Ensong Liu, Jia Yang, Bin Fan, Junpeng He, Liang Sun, Ziyong Feng, Ling Wang, Jian Wu, Tangchun Wang, Hao Cheng, Jin Xing, Hui Meng, Yifan Li, Yongsheng Zhang, Yuanliang Luo, Hongbo Xie, Gang Lan, Xianmei Tao, Ye Li, Jiafeng Yuan, Hao Huang, Kang Sun, Wan Qian, Xiaobo Li, Zhichao Huang, Mingxi Ding, Peiwen Wang, Haoyu Qiu, Jiaying Wang, Feiyue Wang, Shiyou Zhu, Jiacheng Ding, Xiangning Chai, Chaochao Liang, Langchao Wang, Xiaoling Luo, Lihua Sun, Yuzhe Yang, Ying Zhuang, Zhenkun Li, Tao Tian, Lei Zhang, Shaoqiao Zhu, Linnan Chang, Ashley Chen, Lei Wu, Yiquan Ma, Xiaoyan Chen, Fang Ren, Yan Xu, Xun Liu, Siqi Wang, Jian Yang, Huanming Wang, Lin Sun, Chaoyang Ma, Ding Jin, Xin Chen, Gang Nat Commun Article The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19. Nature Publishing Group UK 2021-07-27 /pmc/articles/PMC8316550/ /pubmed/34315889 http://dx.doi.org/10.1038/s41467-021-24482-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Wu, Peng Chen, Dongsheng Ding, Wencheng Wu, Ping Hou, Hongyan Bai, Yong Zhou, Yuwen Li, Kezhen Xiang, Shunian Liu, Panhong Ju, Jia Guo, Ensong Liu, Jia Yang, Bin Fan, Junpeng He, Liang Sun, Ziyong Feng, Ling Wang, Jian Wu, Tangchun Wang, Hao Cheng, Jin Xing, Hui Meng, Yifan Li, Yongsheng Zhang, Yuanliang Luo, Hongbo Xie, Gang Lan, Xianmei Tao, Ye Li, Jiafeng Yuan, Hao Huang, Kang Sun, Wan Qian, Xiaobo Li, Zhichao Huang, Mingxi Ding, Peiwen Wang, Haoyu Qiu, Jiaying Wang, Feiyue Wang, Shiyou Zhu, Jiacheng Ding, Xiangning Chai, Chaochao Liang, Langchao Wang, Xiaoling Luo, Lihua Sun, Yuzhe Yang, Ying Zhuang, Zhenkun Li, Tao Tian, Lei Zhang, Shaoqiao Zhu, Linnan Chang, Ashley Chen, Lei Wu, Yiquan Ma, Xiaoyan Chen, Fang Ren, Yan Xu, Xun Liu, Siqi Wang, Jian Yang, Huanming Wang, Lin Sun, Chaoyang Ma, Ding Jin, Xin Chen, Gang The trans-omics landscape of COVID-19 |
| title | The trans-omics landscape of COVID-19 |
| title_full | The trans-omics landscape of COVID-19 |
| title_fullStr | The trans-omics landscape of COVID-19 |
| title_full_unstemmed | The trans-omics landscape of COVID-19 |
| title_short | The trans-omics landscape of COVID-19 |
| title_sort | trans-omics landscape of covid-19 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316550/ https://www.ncbi.nlm.nih.gov/pubmed/34315889 http://dx.doi.org/10.1038/s41467-021-24482-1 |
| work_keys_str_mv | AT wupeng thetransomicslandscapeofcovid19 AT chendongsheng thetransomicslandscapeofcovid19 AT dingwencheng thetransomicslandscapeofcovid19 AT wuping thetransomicslandscapeofcovid19 AT houhongyan thetransomicslandscapeofcovid19 AT baiyong thetransomicslandscapeofcovid19 AT zhouyuwen thetransomicslandscapeofcovid19 AT likezhen thetransomicslandscapeofcovid19 AT xiangshunian thetransomicslandscapeofcovid19 AT liupanhong thetransomicslandscapeofcovid19 AT jujia thetransomicslandscapeofcovid19 AT guoensong thetransomicslandscapeofcovid19 AT liujia thetransomicslandscapeofcovid19 AT yangbin thetransomicslandscapeofcovid19 AT fanjunpeng thetransomicslandscapeofcovid19 AT heliang thetransomicslandscapeofcovid19 AT sunziyong thetransomicslandscapeofcovid19 AT fengling thetransomicslandscapeofcovid19 AT wangjian thetransomicslandscapeofcovid19 AT wutangchun thetransomicslandscapeofcovid19 AT wanghao thetransomicslandscapeofcovid19 AT chengjin thetransomicslandscapeofcovid19 AT xinghui thetransomicslandscapeofcovid19 AT mengyifan thetransomicslandscapeofcovid19 AT liyongsheng thetransomicslandscapeofcovid19 AT zhangyuanliang thetransomicslandscapeofcovid19 AT luohongbo thetransomicslandscapeofcovid19 AT xiegang thetransomicslandscapeofcovid19 AT lanxianmei thetransomicslandscapeofcovid19 AT taoye thetransomicslandscapeofcovid19 AT lijiafeng thetransomicslandscapeofcovid19 AT yuanhao thetransomicslandscapeofcovid19 AT huangkang thetransomicslandscapeofcovid19 AT sunwan thetransomicslandscapeofcovid19 AT qianxiaobo thetransomicslandscapeofcovid19 AT lizhichao thetransomicslandscapeofcovid19 AT huangmingxi thetransomicslandscapeofcovid19 AT dingpeiwen thetransomicslandscapeofcovid19 AT wanghaoyu thetransomicslandscapeofcovid19 AT qiujiaying thetransomicslandscapeofcovid19 AT wangfeiyue thetransomicslandscapeofcovid19 AT wangshiyou thetransomicslandscapeofcovid19 AT zhujiacheng thetransomicslandscapeofcovid19 AT dingxiangning thetransomicslandscapeofcovid19 AT chaichaochao thetransomicslandscapeofcovid19 AT lianglangchao thetransomicslandscapeofcovid19 AT wangxiaoling thetransomicslandscapeofcovid19 AT luolihua thetransomicslandscapeofcovid19 AT sunyuzhe thetransomicslandscapeofcovid19 AT yangying thetransomicslandscapeofcovid19 AT zhuangzhenkun thetransomicslandscapeofcovid19 AT litao thetransomicslandscapeofcovid19 AT tianlei thetransomicslandscapeofcovid19 AT zhangshaoqiao thetransomicslandscapeofcovid19 AT zhulinnan thetransomicslandscapeofcovid19 AT changashley thetransomicslandscapeofcovid19 AT chenlei thetransomicslandscapeofcovid19 AT wuyiquan thetransomicslandscapeofcovid19 AT maxiaoyan thetransomicslandscapeofcovid19 AT chenfang thetransomicslandscapeofcovid19 AT renyan thetransomicslandscapeofcovid19 AT xuxun thetransomicslandscapeofcovid19 AT liusiqi thetransomicslandscapeofcovid19 AT wangjian thetransomicslandscapeofcovid19 AT yanghuanming thetransomicslandscapeofcovid19 AT wanglin thetransomicslandscapeofcovid19 AT sunchaoyang thetransomicslandscapeofcovid19 AT mading thetransomicslandscapeofcovid19 AT jinxin thetransomicslandscapeofcovid19 AT chengang thetransomicslandscapeofcovid19 AT wupeng transomicslandscapeofcovid19 AT chendongsheng transomicslandscapeofcovid19 AT dingwencheng transomicslandscapeofcovid19 AT wuping transomicslandscapeofcovid19 AT houhongyan transomicslandscapeofcovid19 AT baiyong transomicslandscapeofcovid19 AT zhouyuwen transomicslandscapeofcovid19 AT likezhen transomicslandscapeofcovid19 AT xiangshunian transomicslandscapeofcovid19 AT liupanhong transomicslandscapeofcovid19 AT jujia transomicslandscapeofcovid19 AT guoensong transomicslandscapeofcovid19 AT liujia transomicslandscapeofcovid19 AT yangbin transomicslandscapeofcovid19 AT fanjunpeng transomicslandscapeofcovid19 AT heliang transomicslandscapeofcovid19 AT sunziyong transomicslandscapeofcovid19 AT fengling transomicslandscapeofcovid19 AT wangjian transomicslandscapeofcovid19 AT wutangchun transomicslandscapeofcovid19 AT wanghao transomicslandscapeofcovid19 AT chengjin transomicslandscapeofcovid19 AT xinghui transomicslandscapeofcovid19 AT mengyifan transomicslandscapeofcovid19 AT liyongsheng transomicslandscapeofcovid19 AT zhangyuanliang transomicslandscapeofcovid19 AT luohongbo transomicslandscapeofcovid19 AT xiegang transomicslandscapeofcovid19 AT lanxianmei transomicslandscapeofcovid19 AT taoye transomicslandscapeofcovid19 AT lijiafeng transomicslandscapeofcovid19 AT yuanhao transomicslandscapeofcovid19 AT huangkang transomicslandscapeofcovid19 AT sunwan transomicslandscapeofcovid19 AT qianxiaobo transomicslandscapeofcovid19 AT lizhichao transomicslandscapeofcovid19 AT huangmingxi transomicslandscapeofcovid19 AT dingpeiwen transomicslandscapeofcovid19 AT wanghaoyu transomicslandscapeofcovid19 AT qiujiaying transomicslandscapeofcovid19 AT wangfeiyue transomicslandscapeofcovid19 AT wangshiyou transomicslandscapeofcovid19 AT zhujiacheng transomicslandscapeofcovid19 AT dingxiangning transomicslandscapeofcovid19 AT chaichaochao transomicslandscapeofcovid19 AT lianglangchao transomicslandscapeofcovid19 AT wangxiaoling transomicslandscapeofcovid19 AT luolihua transomicslandscapeofcovid19 AT sunyuzhe transomicslandscapeofcovid19 AT yangying transomicslandscapeofcovid19 AT zhuangzhenkun transomicslandscapeofcovid19 AT litao transomicslandscapeofcovid19 AT tianlei transomicslandscapeofcovid19 AT zhangshaoqiao transomicslandscapeofcovid19 AT zhulinnan transomicslandscapeofcovid19 AT changashley transomicslandscapeofcovid19 AT chenlei transomicslandscapeofcovid19 AT wuyiquan transomicslandscapeofcovid19 AT maxiaoyan transomicslandscapeofcovid19 AT chenfang transomicslandscapeofcovid19 AT renyan transomicslandscapeofcovid19 AT xuxun transomicslandscapeofcovid19 AT liusiqi transomicslandscapeofcovid19 AT wangjian transomicslandscapeofcovid19 AT yanghuanming transomicslandscapeofcovid19 AT wanglin transomicslandscapeofcovid19 AT sunchaoyang transomicslandscapeofcovid19 AT mading transomicslandscapeofcovid19 AT jinxin transomicslandscapeofcovid19 AT chengang transomicslandscapeofcovid19 |