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Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer

The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammato...

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Autores principales: Yoshida, Akira, Takata, Tomoaki, Kanda, Tsutomu, Yamaguchi, Naoyuki, Minami, Hitomi, Nakao, Kazuhiko, Kobayashi, Shinichiro, Eguchi, Susumu, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316560/
https://www.ncbi.nlm.nih.gov/pubmed/34315989
http://dx.doi.org/10.1038/s41598-021-94871-5
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author Yoshida, Akira
Takata, Tomoaki
Kanda, Tsutomu
Yamaguchi, Naoyuki
Minami, Hitomi
Nakao, Kazuhiko
Kobayashi, Shinichiro
Eguchi, Susumu
Isomoto, Hajime
author_facet Yoshida, Akira
Takata, Tomoaki
Kanda, Tsutomu
Yamaguchi, Naoyuki
Minami, Hitomi
Nakao, Kazuhiko
Kobayashi, Shinichiro
Eguchi, Susumu
Isomoto, Hajime
author_sort Yoshida, Akira
collection PubMed
description The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. However, the cytokine crosstalk involved in the oesophageal cancer TME and post-ESD stricture has not been fully elucidated. This study investigated the comprehensive cytokine dynamics following ESD in patients with oesophageal cancer. In addition, the effect of a novel preventive technique for post-ESD stricture, autologous cell sheet engraftment, on cytokine levels was evaluated. Various pro-inflammatory and anti-tumorigenic cytokines were elevated in patients with oesophageal cancer, and ESD transiently influenced cytokine concentrations. IL-1β and TNF-α, two major pro-inflammatory cytokines that induce oesophageal stricture, were significantly suppressed by cell sheet engraftment. In conclusion, this study revealed the distinct cytokine dynamics after ESD in patients with oesophageal cancer, together with the effect of autologous cell sheet engraftment on cytokine fluctuation. These results can accelerate research on the TME and therapeutic strategies for oesophageal cancer.
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spelling pubmed-83165602021-07-29 Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer Yoshida, Akira Takata, Tomoaki Kanda, Tsutomu Yamaguchi, Naoyuki Minami, Hitomi Nakao, Kazuhiko Kobayashi, Shinichiro Eguchi, Susumu Isomoto, Hajime Sci Rep Article The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. However, the cytokine crosstalk involved in the oesophageal cancer TME and post-ESD stricture has not been fully elucidated. This study investigated the comprehensive cytokine dynamics following ESD in patients with oesophageal cancer. In addition, the effect of a novel preventive technique for post-ESD stricture, autologous cell sheet engraftment, on cytokine levels was evaluated. Various pro-inflammatory and anti-tumorigenic cytokines were elevated in patients with oesophageal cancer, and ESD transiently influenced cytokine concentrations. IL-1β and TNF-α, two major pro-inflammatory cytokines that induce oesophageal stricture, were significantly suppressed by cell sheet engraftment. In conclusion, this study revealed the distinct cytokine dynamics after ESD in patients with oesophageal cancer, together with the effect of autologous cell sheet engraftment on cytokine fluctuation. These results can accelerate research on the TME and therapeutic strategies for oesophageal cancer. Nature Publishing Group UK 2021-07-27 /pmc/articles/PMC8316560/ /pubmed/34315989 http://dx.doi.org/10.1038/s41598-021-94871-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yoshida, Akira
Takata, Tomoaki
Kanda, Tsutomu
Yamaguchi, Naoyuki
Minami, Hitomi
Nakao, Kazuhiko
Kobayashi, Shinichiro
Eguchi, Susumu
Isomoto, Hajime
Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_full Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_fullStr Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_full_unstemmed Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_short Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_sort impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316560/
https://www.ncbi.nlm.nih.gov/pubmed/34315989
http://dx.doi.org/10.1038/s41598-021-94871-5
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