Cargando…

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization

Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection, there is limited understanding of genes and pathways that contribute to COVID-19. Here, we integrate a genome-wide association study of COVID-19 hospitalization (7,885 cases and 961,804 controls from COVID-19...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pathak, Gita A., Singh, Kritika, Miller-Fleming, Tyne W., Wendt, Frank R., Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K., Mancuso, Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316582/ https://www.ncbi.nlm.nih.gov/pubmed/34315903 http://dx.doi.org/10.1038/s41467-021-24824-z

Ejemplares similares

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization
por: Pathak, Gita A, et al.
Publicado: (2020)

Integrative analyses identify genes and their functional consequences underlying COVID-19 hospitalization
por: Singh, Kritika, et al.
Publicado: (2021)

ACE2 Netlas: In-silico functional characterization and drug-gene interactions of ACE2 gene network to understand its potential involvement in COVID-19 susceptibility
por: Pathak, Gita A, et al.
Publicado: (2020)

Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes
por: Wendt, Frank R., et al.
Publicado: (2022)

ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility
por: Pathak, Gita A., et al.
Publicado: (2021)

Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent
por: De Lillo, Antonella, et al.
Publicado: (2023)

twas_sim, a Python-based tool for simulation and power analysis of transcriptome-wide association analysis
por: Wang, Xinran, et al.
Publicado: (2023)

Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective
por: Wendt, Frank R., et al.
Publicado: (2020)

PHENOME-WIDE GENETIC CORRELATION AND CAUSALITY OF COVID-19 SEVERITY HIGHLIGHTS OVERLAP WITH SUBSTANCE-USE TRAITS
por: Pathak, Gita, et al.
Publicado: (2021)

Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort
por: Wendt, Frank R., et al.
Publicado: (2020)

Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders
por: Wendt, Frank R, et al.
Publicado: (2019)

Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
por: Wendt, Frank R, et al.
Publicado: (2021)

Multivariate genome-wide analysis of education, socioeconomic status, and brain phenome
por: Wendt, Frank R., et al.
Publicado: (2020)

Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry
por: Pathak, Gita A., et al.
Publicado: (2020)

Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk
por: De Angelis, Flavio, et al.
Publicado: (2021)

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
por: Hou, Kangcheng, et al.
Publicado: (2019)

The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study
por: Cabrera-Mendoza, Brenda, et al.
Publicado: (2022)

Calibrated prediction intervals for polygenic scores across diverse contexts
por: Hou, Kangcheng, et al.
Publicado: (2023)

Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
por: Koller, Dora, et al.
Publicado: (2022)

Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
por: Koller, Dora, et al.
Publicado: (2023)

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits
por: Johnson, Ruth, et al.
Publicado: (2021)

Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis
por: D’Antona, Salvatore, et al.
Publicado: (2023)

Efficient variance components analysis across millions of genomes
por: Pazokitoroudi, Ali, et al.
Publicado: (2020)

The physical and psychiatric health conditions related to autism genetic scores, across genetic ancestries, sexes and age-groups in electronic health records
por: Niarchou, Maria, et al.
Publicado: (2023)

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
por: Ding, Yi, et al.
Publicado: (2022)

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality
por: Polimanti, Renato, et al.
Publicado: (2021)

Impact of cross-ancestry genetic architecture on GWAS in admixed populations
por: Mester, Rachel, et al.
Publicado: (2023)

Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events
por: Wendt, Frank R., et al.
Publicado: (2022)

Inferring archaic introgression from hominin genetic data
por: Gopalan, Shyamalika, et al.
Publicado: (2021)

Human genetic admixture through the lens of population genomics
por: Gopalan, Shyamalika, et al.
Publicado: (2022)

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies
por: Feng, Helian, et al.
Publicado: (2021)

Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data
por: Quintero Reis, Andrea, et al.
Publicado: (2023)

Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition
por: Muniz Carvalho, Carolina, et al.
Publicado: (2021)

Powerful eQTL mapping through low-coverage RNA sequencing
por: Schwarz, Tommer, et al.
Publicado: (2022)

Polygenic scoring accuracy varies across the genetic ancestry continuum
por: Ding, Yi, et al.
Publicado: (2023)

Enhanced Methods for Local Ancestry Assignment in Sequenced Admixed Individuals
por: Brown, Robert, et al.
Publicado: (2014)

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder
por: Wendt, Frank R, et al.
Publicado: (2022)

Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis
por: De Lillo, Antonella, et al.
Publicado: (2020)

Sex differences in the polygenic architecture of hearing problems in adults
por: De Angelis, Flavio, et al.
Publicado: (2023)

Optimized design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis
por: Mandric, Igor, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_266etk7gtfoen61g6biup985vl