Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Neutralizing antibodies (nAbs) hold promise as therapeutics against COVID-19. Here, we describe protein engineering and modular design principles that have led to the development of synthetic bivalent and tetravalent nAbs against SARS-CoV-2. The best nAb targets the host receptor binding site of the...

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Detalles Bibliográficos
Autores principales: Miersch, Shane, Li, Zhijie, Saberianfar, Reza, Ustav, Mart, Brett Case, James, Blazer, Levi, Chen, Chao, Ye, Wei, Pavlenco, Alevtina, Gorelik, Maryna, Garcia Perez, Julia, Subramania, Suryasree, Singh, Serena, Ploder, Lynda, Ganaie, Safder, Chen, Rita E., Leung, Daisy W., Pandolfi, Pier Paolo, Novelli, Giuseppe, Matusali, Giulia, Colavita, Francesca, Capobianchi, Maria R., Jain, Suresh, Gupta, J.B., Amarasinghe, Gaya K., Diamond, Michael S., Rini, James, Sidhu, Sachdev S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316672/
https://www.ncbi.nlm.nih.gov/pubmed/34329642
http://dx.doi.org/10.1016/j.jmb.2021.167177

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