GLP-1 Receptor: A New Target for Sepsis

Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. H...

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Detalles Bibliográficos
Autores principales: Yang, Fuxun, Zeng, Fan, Luo, Xiaoxiu, Lei, Yu, Li, Jiajia, Lu, Sen, Huang, Xiaobo, Lan, Yunping, Liu, Rongan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316682/
https://www.ncbi.nlm.nih.gov/pubmed/34335269
http://dx.doi.org/10.3389/fphar.2021.706908
Descripción
Sumario:Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.

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