GLP-1 Receptor: A New Target for Sepsis

Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. H...

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Autores principales: Yang, Fuxun, Zeng, Fan, Luo, Xiaoxiu, Lei, Yu, Li, Jiajia, Lu, Sen, Huang, Xiaobo, Lan, Yunping, Liu, Rongan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316682/
https://www.ncbi.nlm.nih.gov/pubmed/34335269
http://dx.doi.org/10.3389/fphar.2021.706908
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author Yang, Fuxun
Zeng, Fan
Luo, Xiaoxiu
Lei, Yu
Li, Jiajia
Lu, Sen
Huang, Xiaobo
Lan, Yunping
Liu, Rongan
author_facet Yang, Fuxun
Zeng, Fan
Luo, Xiaoxiu
Lei, Yu
Li, Jiajia
Lu, Sen
Huang, Xiaobo
Lan, Yunping
Liu, Rongan
author_sort Yang, Fuxun
collection PubMed
description Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.
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spelling pubmed-83166822021-07-29 GLP-1 Receptor: A New Target for Sepsis Yang, Fuxun Zeng, Fan Luo, Xiaoxiu Lei, Yu Li, Jiajia Lu, Sen Huang, Xiaobo Lan, Yunping Liu, Rongan Front Pharmacol Pharmacology Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8316682/ /pubmed/34335269 http://dx.doi.org/10.3389/fphar.2021.706908 Text en Copyright © 2021 Yang, Zeng, Luo, Lei, Li, Lu, Huang, Lan and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yang, Fuxun
Zeng, Fan
Luo, Xiaoxiu
Lei, Yu
Li, Jiajia
Lu, Sen
Huang, Xiaobo
Lan, Yunping
Liu, Rongan
GLP-1 Receptor: A New Target for Sepsis
title GLP-1 Receptor: A New Target for Sepsis
title_full GLP-1 Receptor: A New Target for Sepsis
title_fullStr GLP-1 Receptor: A New Target for Sepsis
title_full_unstemmed GLP-1 Receptor: A New Target for Sepsis
title_short GLP-1 Receptor: A New Target for Sepsis
title_sort glp-1 receptor: a new target for sepsis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316682/
https://www.ncbi.nlm.nih.gov/pubmed/34335269
http://dx.doi.org/10.3389/fphar.2021.706908
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