The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer

Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvir...

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Autores principales: Luo, Lumeng, Liu, Peiyi, Zhao, Kuaile, Zhao, Weixin, Zhang, Xiaofei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316686/
https://www.ncbi.nlm.nih.gov/pubmed/34336687
http://dx.doi.org/10.3389/fonc.2021.698844
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author Luo, Lumeng
Liu, Peiyi
Zhao, Kuaile
Zhao, Weixin
Zhang, Xiaofei
author_facet Luo, Lumeng
Liu, Peiyi
Zhao, Kuaile
Zhao, Weixin
Zhang, Xiaofei
author_sort Luo, Lumeng
collection PubMed
description Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvironment of brain is distinctly different from microenvironments of extracranial lesions. In this review, we summarized the process of brain metastases across the barrier and revealed that brain is not completely immune-privileged. We comprehensively described the specific components of immune microenvironment for brain metastases such as central nervous system-derived antigen-presenting cells, microglia and astrocytes. Besides, the difference of immune microenvironment between brain metastases and primary foci of lung was particularly demonstrated.
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spelling pubmed-83166862021-07-29 The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer Luo, Lumeng Liu, Peiyi Zhao, Kuaile Zhao, Weixin Zhang, Xiaofei Front Oncol Oncology Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvironment of brain is distinctly different from microenvironments of extracranial lesions. In this review, we summarized the process of brain metastases across the barrier and revealed that brain is not completely immune-privileged. We comprehensively described the specific components of immune microenvironment for brain metastases such as central nervous system-derived antigen-presenting cells, microglia and astrocytes. Besides, the difference of immune microenvironment between brain metastases and primary foci of lung was particularly demonstrated. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8316686/ /pubmed/34336687 http://dx.doi.org/10.3389/fonc.2021.698844 Text en Copyright © 2021 Luo, Liu, Zhao, Zhao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Luo, Lumeng
Liu, Peiyi
Zhao, Kuaile
Zhao, Weixin
Zhang, Xiaofei
The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer
title The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer
title_full The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer
title_fullStr The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer
title_full_unstemmed The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer
title_short The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer
title_sort immune microenvironment in brain metastases of non-small cell lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316686/
https://www.ncbi.nlm.nih.gov/pubmed/34336687
http://dx.doi.org/10.3389/fonc.2021.698844
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