Cargando…

Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study

Aim: The present study was established to investigate the use of the serum cystatin C/prealbumin (Cys-C/PAB) ratio as a predictive factor for long-term prognosis in patients with chronic heart failure. Methods: We divided our retrospective cohort of 6,311 patients admitted to hospital due to an epis...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Chuanhe, Han, Su, Tong, Fei, Li, Ying, Li, Zhichao, Sun, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316687/
https://www.ncbi.nlm.nih.gov/pubmed/34336949
http://dx.doi.org/10.3389/fcvm.2021.684919
_version_ 1783729913472221184
author Wang, Chuanhe
Han, Su
Tong, Fei
Li, Ying
Li, Zhichao
Sun, Zhijun
author_facet Wang, Chuanhe
Han, Su
Tong, Fei
Li, Ying
Li, Zhichao
Sun, Zhijun
author_sort Wang, Chuanhe
collection PubMed
description Aim: The present study was established to investigate the use of the serum cystatin C/prealbumin (Cys-C/PAB) ratio as a predictive factor for long-term prognosis in patients with chronic heart failure. Methods: We divided our retrospective cohort of 6,311 patients admitted to hospital due to an episode of heart failure (HF) into three groups according to the Cys-C/PAB ratio. The endpoints were cardiovascular and all-cause mortality. Median follow-up time were 3.3 years (2–8 years), during which 2,945 (46.7%) patients died. Results: The Cys-C/PAB ratio was revealed to be an independent predictor of cardiovascular mortality (HR: 1.12, 95% CI: 1.15–1.23, P < 0.01) and all-cause mortality (HR: 1.19, 95% CI: 1.13–1.24, P < 0.01) by multivariable Cox analysis. Integrated discrimination improvement (IDI) showed that the Cys-C/PAB ratio in conjunction with the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) conferred a significant improvement in predicting individual risks of cardiovascular (P = 0.023) and all-cause (P = 0.028) mortality. For those with a high Cys-C/PAB ratio in combination with a high NT-proBNP level, the long-term cardiovascular mortality risk ratio was 8.6-times higher than for those with low values, and 7.51-times for all-cause mortality. Our study also showed that Cys-C/PAB and NT-proBNP in combination displayed higher value for the prediction of cardiovascular and all-cause in-hospital mortality in patients with HF. Conclusions: The Cys-C/PAB ratio is valuable for predicting cardiovascular and all-cause mortality in patients with HF and offers additional information to that provided by NT-proBNP.
format Online
Article
Text
id pubmed-8316687
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83166872021-07-29 Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study Wang, Chuanhe Han, Su Tong, Fei Li, Ying Li, Zhichao Sun, Zhijun Front Cardiovasc Med Cardiovascular Medicine Aim: The present study was established to investigate the use of the serum cystatin C/prealbumin (Cys-C/PAB) ratio as a predictive factor for long-term prognosis in patients with chronic heart failure. Methods: We divided our retrospective cohort of 6,311 patients admitted to hospital due to an episode of heart failure (HF) into three groups according to the Cys-C/PAB ratio. The endpoints were cardiovascular and all-cause mortality. Median follow-up time were 3.3 years (2–8 years), during which 2,945 (46.7%) patients died. Results: The Cys-C/PAB ratio was revealed to be an independent predictor of cardiovascular mortality (HR: 1.12, 95% CI: 1.15–1.23, P < 0.01) and all-cause mortality (HR: 1.19, 95% CI: 1.13–1.24, P < 0.01) by multivariable Cox analysis. Integrated discrimination improvement (IDI) showed that the Cys-C/PAB ratio in conjunction with the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) conferred a significant improvement in predicting individual risks of cardiovascular (P = 0.023) and all-cause (P = 0.028) mortality. For those with a high Cys-C/PAB ratio in combination with a high NT-proBNP level, the long-term cardiovascular mortality risk ratio was 8.6-times higher than for those with low values, and 7.51-times for all-cause mortality. Our study also showed that Cys-C/PAB and NT-proBNP in combination displayed higher value for the prediction of cardiovascular and all-cause in-hospital mortality in patients with HF. Conclusions: The Cys-C/PAB ratio is valuable for predicting cardiovascular and all-cause mortality in patients with HF and offers additional information to that provided by NT-proBNP. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8316687/ /pubmed/34336949 http://dx.doi.org/10.3389/fcvm.2021.684919 Text en Copyright © 2021 Wang, Han, Tong, Li, Li and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wang, Chuanhe
Han, Su
Tong, Fei
Li, Ying
Li, Zhichao
Sun, Zhijun
Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study
title Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study
title_full Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study
title_fullStr Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study
title_full_unstemmed Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study
title_short Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study
title_sort predictive value of the serum cystatin c/prealbumin ratio in combination with nt-probnp levels for long-term prognosis in chronic heart failure patients: a retrospective cohort study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316687/
https://www.ncbi.nlm.nih.gov/pubmed/34336949
http://dx.doi.org/10.3389/fcvm.2021.684919
work_keys_str_mv AT wangchuanhe predictivevalueoftheserumcystatincprealbuminratioincombinationwithntprobnplevelsforlongtermprognosisinchronicheartfailurepatientsaretrospectivecohortstudy
AT hansu predictivevalueoftheserumcystatincprealbuminratioincombinationwithntprobnplevelsforlongtermprognosisinchronicheartfailurepatientsaretrospectivecohortstudy
AT tongfei predictivevalueoftheserumcystatincprealbuminratioincombinationwithntprobnplevelsforlongtermprognosisinchronicheartfailurepatientsaretrospectivecohortstudy
AT liying predictivevalueoftheserumcystatincprealbuminratioincombinationwithntprobnplevelsforlongtermprognosisinchronicheartfailurepatientsaretrospectivecohortstudy
AT lizhichao predictivevalueoftheserumcystatincprealbuminratioincombinationwithntprobnplevelsforlongtermprognosisinchronicheartfailurepatientsaretrospectivecohortstudy
AT sunzhijun predictivevalueoftheserumcystatincprealbuminratioincombinationwithntprobnplevelsforlongtermprognosisinchronicheartfailurepatientsaretrospectivecohortstudy