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Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients

BACKGROUND: At present, the value of lipid indicators in evaluating the prognosis of colorectal cancer is still relatively limited. AIM: To evaluate the value of a novel parameter for colorectal cancer (CRC) prognosis scoring based on preoperative serum lipid levels. METHODS: Four key serum lipid fa...

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Autores principales: Gu, Jun-Nan, Yao, Shuang, Cao, Ying-Hao, Deng, Sheng-He, Mao, Fu-Wei, Jiang, Hong-Yu, He, Yang-Ting, Li, Xin-Ying, Ke, Song-Qing, Li, Hui-Li, Li, Hang, Liu, Xing-Hua, Liu, Hong-Li, Wang, Ji-Liang, Wu, Ke, Liu, Li, Cai, Kai-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316850/
https://www.ncbi.nlm.nih.gov/pubmed/34354802
http://dx.doi.org/10.4240/wjgs.v13.i7.689
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author Gu, Jun-Nan
Yao, Shuang
Cao, Ying-Hao
Deng, Sheng-He
Mao, Fu-Wei
Jiang, Hong-Yu
He, Yang-Ting
Li, Xin-Ying
Ke, Song-Qing
Li, Hui-Li
Li, Hang
Liu, Xing-Hua
Liu, Hong-Li
Wang, Ji-Liang
Wu, Ke
Liu, Li
Cai, Kai-Lin
author_facet Gu, Jun-Nan
Yao, Shuang
Cao, Ying-Hao
Deng, Sheng-He
Mao, Fu-Wei
Jiang, Hong-Yu
He, Yang-Ting
Li, Xin-Ying
Ke, Song-Qing
Li, Hui-Li
Li, Hang
Liu, Xing-Hua
Liu, Hong-Li
Wang, Ji-Liang
Wu, Ke
Liu, Li
Cai, Kai-Lin
author_sort Gu, Jun-Nan
collection PubMed
description BACKGROUND: At present, the value of lipid indicators in evaluating the prognosis of colorectal cancer is still relatively limited. AIM: To evaluate the value of a novel parameter for colorectal cancer (CRC) prognosis scoring based on preoperative serum lipid levels. METHODS: Four key serum lipid factors, namely, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), were detected. Two representative ratios, HDL-C-LDL-C ratio (HLR) and ApoA1-ApoB ratio (ABR) were calculated. The relationship of these parameters with the prognosis of CRC patients including progression-free survival (PFS) and overall survival (OS) was analyzed by Kaplan-Meier plot and Cox proportional hazards regression. A novel lipoprotein cholesterol-apolipoprotein (LA) score based on HLR and ABR was established and its value in prognosis evaluation for CRC patients was explored. RESULTS: Multivariate Cox proportional hazards regression analysis of PFS and OS showed that HDL-C, ApoA1, HLR, and ABR were positively associated with the prognosis of CRC patients. LA score was independently associated with a good prognosis in resectable CRC patients. Data processing of a dummy variable showed that the prognosis of patients with higher LA scores is better than that with lower LA scores. CONCLUSION: The newly established LA score might serve as a better predictor of the prognosis of resectable CRC patients.
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spelling pubmed-83168502021-08-04 Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients Gu, Jun-Nan Yao, Shuang Cao, Ying-Hao Deng, Sheng-He Mao, Fu-Wei Jiang, Hong-Yu He, Yang-Ting Li, Xin-Ying Ke, Song-Qing Li, Hui-Li Li, Hang Liu, Xing-Hua Liu, Hong-Li Wang, Ji-Liang Wu, Ke Liu, Li Cai, Kai-Lin World J Gastrointest Surg Retrospective Study BACKGROUND: At present, the value of lipid indicators in evaluating the prognosis of colorectal cancer is still relatively limited. AIM: To evaluate the value of a novel parameter for colorectal cancer (CRC) prognosis scoring based on preoperative serum lipid levels. METHODS: Four key serum lipid factors, namely, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), were detected. Two representative ratios, HDL-C-LDL-C ratio (HLR) and ApoA1-ApoB ratio (ABR) were calculated. The relationship of these parameters with the prognosis of CRC patients including progression-free survival (PFS) and overall survival (OS) was analyzed by Kaplan-Meier plot and Cox proportional hazards regression. A novel lipoprotein cholesterol-apolipoprotein (LA) score based on HLR and ABR was established and its value in prognosis evaluation for CRC patients was explored. RESULTS: Multivariate Cox proportional hazards regression analysis of PFS and OS showed that HDL-C, ApoA1, HLR, and ABR were positively associated with the prognosis of CRC patients. LA score was independently associated with a good prognosis in resectable CRC patients. Data processing of a dummy variable showed that the prognosis of patients with higher LA scores is better than that with lower LA scores. CONCLUSION: The newly established LA score might serve as a better predictor of the prognosis of resectable CRC patients. Baishideng Publishing Group Inc 2021-07-27 2021-07-27 /pmc/articles/PMC8316850/ /pubmed/34354802 http://dx.doi.org/10.4240/wjgs.v13.i7.689 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Study
Gu, Jun-Nan
Yao, Shuang
Cao, Ying-Hao
Deng, Sheng-He
Mao, Fu-Wei
Jiang, Hong-Yu
He, Yang-Ting
Li, Xin-Ying
Ke, Song-Qing
Li, Hui-Li
Li, Hang
Liu, Xing-Hua
Liu, Hong-Li
Wang, Ji-Liang
Wu, Ke
Liu, Li
Cai, Kai-Lin
Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
title Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
title_full Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
title_fullStr Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
title_full_unstemmed Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
title_short Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
title_sort novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316850/
https://www.ncbi.nlm.nih.gov/pubmed/34354802
http://dx.doi.org/10.4240/wjgs.v13.i7.689
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