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Role and mechanism of neural stem cells of the subventricular zone in glioblastoma

Glioblastoma multiforme (GBM), the most frequently occurring malignant brain tumor in adults, remains mostly untreatable. Because of the heterogeneity of invasive gliomas and drug resistance associated with the tumor microenvironment, the prognosis is poor, and the survival rate of patients is low....

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Autores principales: Zhang, Gui-Long, Wang, Chuan-Fang, Qian, Cheng, Ji, Yun-Xiang, Wang, Ye-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316865/
https://www.ncbi.nlm.nih.gov/pubmed/34367482
http://dx.doi.org/10.4252/wjsc.v13.i7.877
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author Zhang, Gui-Long
Wang, Chuan-Fang
Qian, Cheng
Ji, Yun-Xiang
Wang, Ye-Zhong
author_facet Zhang, Gui-Long
Wang, Chuan-Fang
Qian, Cheng
Ji, Yun-Xiang
Wang, Ye-Zhong
author_sort Zhang, Gui-Long
collection PubMed
description Glioblastoma multiforme (GBM), the most frequently occurring malignant brain tumor in adults, remains mostly untreatable. Because of the heterogeneity of invasive gliomas and drug resistance associated with the tumor microenvironment, the prognosis is poor, and the survival rate of patients is low. Communication between GBMs and non-glioma cells in the tumor microenvironment plays a vital role in tumor growth and recurrence. Emerging data have suggested that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells-of-origin of gliomas, and SVZ NSC involvement is associated with the progression and recurrence of GBM. This review highlights the interaction between SVZ NSCs and gliomas, summarizes current findings on the crosstalk between gliomas and other non-glioma cells, and describes the links between SVZ NSCs and gliomas. We also discuss the role and mechanism of SVZ NSCs in glioblastoma, as well as the interventions targeting the SVZ and their therapeutic implications in glioblastoma. Taken together, understanding the biological mechanism of glioma-NSC interactions can lead to new therapeutic strategies for GBM.
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spelling pubmed-83168652021-08-05 Role and mechanism of neural stem cells of the subventricular zone in glioblastoma Zhang, Gui-Long Wang, Chuan-Fang Qian, Cheng Ji, Yun-Xiang Wang, Ye-Zhong World J Stem Cells Review Glioblastoma multiforme (GBM), the most frequently occurring malignant brain tumor in adults, remains mostly untreatable. Because of the heterogeneity of invasive gliomas and drug resistance associated with the tumor microenvironment, the prognosis is poor, and the survival rate of patients is low. Communication between GBMs and non-glioma cells in the tumor microenvironment plays a vital role in tumor growth and recurrence. Emerging data have suggested that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells-of-origin of gliomas, and SVZ NSC involvement is associated with the progression and recurrence of GBM. This review highlights the interaction between SVZ NSCs and gliomas, summarizes current findings on the crosstalk between gliomas and other non-glioma cells, and describes the links between SVZ NSCs and gliomas. We also discuss the role and mechanism of SVZ NSCs in glioblastoma, as well as the interventions targeting the SVZ and their therapeutic implications in glioblastoma. Taken together, understanding the biological mechanism of glioma-NSC interactions can lead to new therapeutic strategies for GBM. Baishideng Publishing Group Inc 2021-07-26 2021-07-26 /pmc/articles/PMC8316865/ /pubmed/34367482 http://dx.doi.org/10.4252/wjsc.v13.i7.877 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Zhang, Gui-Long
Wang, Chuan-Fang
Qian, Cheng
Ji, Yun-Xiang
Wang, Ye-Zhong
Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
title Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
title_full Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
title_fullStr Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
title_full_unstemmed Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
title_short Role and mechanism of neural stem cells of the subventricular zone in glioblastoma
title_sort role and mechanism of neural stem cells of the subventricular zone in glioblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316865/
https://www.ncbi.nlm.nih.gov/pubmed/34367482
http://dx.doi.org/10.4252/wjsc.v13.i7.877
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