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Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives
Since it was first reported in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world to cause the ongoing pandemic. Although the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system, liver enzy...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316914/ https://www.ncbi.nlm.nih.gov/pubmed/34366609 http://dx.doi.org/10.3748/wjg.v27.i27.4358 |
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author | Huang, Yi-Ke Li, Yu-Jia Li, Bin Wang, Pan Wang, Qing-Hua |
author_facet | Huang, Yi-Ke Li, Yu-Jia Li, Bin Wang, Pan Wang, Qing-Hua |
author_sort | Huang, Yi-Ke |
collection | PubMed |
description | Since it was first reported in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world to cause the ongoing pandemic. Although the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system, liver enzyme abnormalities exist in around half of the cases, which indicate liver injury, and raise clinical concern. At present, there is no consensus whether the liver injury is directly caused by viral replication in the liver tissue or indirectly by the systemic inflammatory response. This review aims to summarize the clinical manifestations and to explore the underlying mechanisms of liver dysfunction in patients with SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8316914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-83169142021-08-05 Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives Huang, Yi-Ke Li, Yu-Jia Li, Bin Wang, Pan Wang, Qing-Hua World J Gastroenterol Minireviews Since it was first reported in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world to cause the ongoing pandemic. Although the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system, liver enzyme abnormalities exist in around half of the cases, which indicate liver injury, and raise clinical concern. At present, there is no consensus whether the liver injury is directly caused by viral replication in the liver tissue or indirectly by the systemic inflammatory response. This review aims to summarize the clinical manifestations and to explore the underlying mechanisms of liver dysfunction in patients with SARS-CoV-2 infection. Baishideng Publishing Group Inc 2021-07-21 2021-07-21 /pmc/articles/PMC8316914/ /pubmed/34366609 http://dx.doi.org/10.3748/wjg.v27.i27.4358 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Huang, Yi-Ke Li, Yu-Jia Li, Bin Wang, Pan Wang, Qing-Hua Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives |
title | Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives |
title_full | Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives |
title_fullStr | Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives |
title_full_unstemmed | Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives |
title_short | Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives |
title_sort | dysregulated liver function in sars-cov-2 infection: current understanding and perspectives |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316914/ https://www.ncbi.nlm.nih.gov/pubmed/34366609 http://dx.doi.org/10.3748/wjg.v27.i27.4358 |
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