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Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19

Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subse...

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Autores principales: Oliva, Alessandra, Miele, Maria Claudia, Di Timoteo, Federica, De Angelis, Massimiliano, Mauro, Vera, Aronica, Raissa, Al Ismail, Dania, Ceccarelli, Giancarlo, Pinacchio, Claudia, d’Ettorre, Gabriella, Mascellino, Maria Teresa, Mastroianni, Claudio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316921/
https://www.ncbi.nlm.nih.gov/pubmed/34335624
http://dx.doi.org/10.3389/fimmu.2021.708149
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author Oliva, Alessandra
Miele, Maria Claudia
Di Timoteo, Federica
De Angelis, Massimiliano
Mauro, Vera
Aronica, Raissa
Al Ismail, Dania
Ceccarelli, Giancarlo
Pinacchio, Claudia
d’Ettorre, Gabriella
Mascellino, Maria Teresa
Mastroianni, Claudio M.
author_facet Oliva, Alessandra
Miele, Maria Claudia
Di Timoteo, Federica
De Angelis, Massimiliano
Mauro, Vera
Aronica, Raissa
Al Ismail, Dania
Ceccarelli, Giancarlo
Pinacchio, Claudia
d’Ettorre, Gabriella
Mascellino, Maria Teresa
Mastroianni, Claudio M.
author_sort Oliva, Alessandra
collection PubMed
description Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subsequent bloodstream infection (BSI). Furthermore, we looked at the potential predictive role of TM and ID markers on Intensive Care Unit (ICU) admission and in-hospital mortality. Over March–July 2020, 45 COVID-19 patients were enrolled. Markers of MT [LPB (Lipopolysacharide Binding Protein) and EndoCab IgM] and ID [I-FABP (Intestinal Fatty Acid Binding Protein)] were evaluated at COVID-19 diagnosis and after 7 days. As a control group, age- and gender-matched healthy donors (HDs) enrolled during the same study period were included. Median age was 66 (56-71) years. Twenty-one (46.6%) were admitted to ICU and mortality was 22% (10/45). Compared to HD, a high degree of MT and ID was observed. ICU patients had higher levels of MT, but not of ID, than non-ICU ones. Likewise, patients with BSI had lower EndoCab IgM than non-BSI. Interestingly, patients with high degree of MT and low ID were likely to be admitted to ICU (AUC 0.822). Patients with COVID-19 exhibited high level of MT, especially subjects admitted to ICU. COVID-19 is associated with gut permeability.
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spelling pubmed-83169212021-07-29 Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 Oliva, Alessandra Miele, Maria Claudia Di Timoteo, Federica De Angelis, Massimiliano Mauro, Vera Aronica, Raissa Al Ismail, Dania Ceccarelli, Giancarlo Pinacchio, Claudia d’Ettorre, Gabriella Mascellino, Maria Teresa Mastroianni, Claudio M. Front Immunol Immunology Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subsequent bloodstream infection (BSI). Furthermore, we looked at the potential predictive role of TM and ID markers on Intensive Care Unit (ICU) admission and in-hospital mortality. Over March–July 2020, 45 COVID-19 patients were enrolled. Markers of MT [LPB (Lipopolysacharide Binding Protein) and EndoCab IgM] and ID [I-FABP (Intestinal Fatty Acid Binding Protein)] were evaluated at COVID-19 diagnosis and after 7 days. As a control group, age- and gender-matched healthy donors (HDs) enrolled during the same study period were included. Median age was 66 (56-71) years. Twenty-one (46.6%) were admitted to ICU and mortality was 22% (10/45). Compared to HD, a high degree of MT and ID was observed. ICU patients had higher levels of MT, but not of ID, than non-ICU ones. Likewise, patients with BSI had lower EndoCab IgM than non-BSI. Interestingly, patients with high degree of MT and low ID were likely to be admitted to ICU (AUC 0.822). Patients with COVID-19 exhibited high level of MT, especially subjects admitted to ICU. COVID-19 is associated with gut permeability. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8316921/ /pubmed/34335624 http://dx.doi.org/10.3389/fimmu.2021.708149 Text en Copyright © 2021 Oliva, Miele, Di Timoteo, De Angelis, Mauro, Aronica, Al Ismail, Ceccarelli, Pinacchio, d’Ettorre, Mascellino and Mastroianni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Oliva, Alessandra
Miele, Maria Claudia
Di Timoteo, Federica
De Angelis, Massimiliano
Mauro, Vera
Aronica, Raissa
Al Ismail, Dania
Ceccarelli, Giancarlo
Pinacchio, Claudia
d’Ettorre, Gabriella
Mascellino, Maria Teresa
Mastroianni, Claudio M.
Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
title Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
title_full Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
title_fullStr Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
title_full_unstemmed Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
title_short Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
title_sort persistent systemic microbial translocation and intestinal damage during coronavirus disease-19
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316921/
https://www.ncbi.nlm.nih.gov/pubmed/34335624
http://dx.doi.org/10.3389/fimmu.2021.708149
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