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Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19
Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subse...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316921/ https://www.ncbi.nlm.nih.gov/pubmed/34335624 http://dx.doi.org/10.3389/fimmu.2021.708149 |
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author | Oliva, Alessandra Miele, Maria Claudia Di Timoteo, Federica De Angelis, Massimiliano Mauro, Vera Aronica, Raissa Al Ismail, Dania Ceccarelli, Giancarlo Pinacchio, Claudia d’Ettorre, Gabriella Mascellino, Maria Teresa Mastroianni, Claudio M. |
author_facet | Oliva, Alessandra Miele, Maria Claudia Di Timoteo, Federica De Angelis, Massimiliano Mauro, Vera Aronica, Raissa Al Ismail, Dania Ceccarelli, Giancarlo Pinacchio, Claudia d’Ettorre, Gabriella Mascellino, Maria Teresa Mastroianni, Claudio M. |
author_sort | Oliva, Alessandra |
collection | PubMed |
description | Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subsequent bloodstream infection (BSI). Furthermore, we looked at the potential predictive role of TM and ID markers on Intensive Care Unit (ICU) admission and in-hospital mortality. Over March–July 2020, 45 COVID-19 patients were enrolled. Markers of MT [LPB (Lipopolysacharide Binding Protein) and EndoCab IgM] and ID [I-FABP (Intestinal Fatty Acid Binding Protein)] were evaluated at COVID-19 diagnosis and after 7 days. As a control group, age- and gender-matched healthy donors (HDs) enrolled during the same study period were included. Median age was 66 (56-71) years. Twenty-one (46.6%) were admitted to ICU and mortality was 22% (10/45). Compared to HD, a high degree of MT and ID was observed. ICU patients had higher levels of MT, but not of ID, than non-ICU ones. Likewise, patients with BSI had lower EndoCab IgM than non-BSI. Interestingly, patients with high degree of MT and low ID were likely to be admitted to ICU (AUC 0.822). Patients with COVID-19 exhibited high level of MT, especially subjects admitted to ICU. COVID-19 is associated with gut permeability. |
format | Online Article Text |
id | pubmed-8316921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83169212021-07-29 Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 Oliva, Alessandra Miele, Maria Claudia Di Timoteo, Federica De Angelis, Massimiliano Mauro, Vera Aronica, Raissa Al Ismail, Dania Ceccarelli, Giancarlo Pinacchio, Claudia d’Ettorre, Gabriella Mascellino, Maria Teresa Mastroianni, Claudio M. Front Immunol Immunology Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of subsequent bloodstream infection (BSI). Furthermore, we looked at the potential predictive role of TM and ID markers on Intensive Care Unit (ICU) admission and in-hospital mortality. Over March–July 2020, 45 COVID-19 patients were enrolled. Markers of MT [LPB (Lipopolysacharide Binding Protein) and EndoCab IgM] and ID [I-FABP (Intestinal Fatty Acid Binding Protein)] were evaluated at COVID-19 diagnosis and after 7 days. As a control group, age- and gender-matched healthy donors (HDs) enrolled during the same study period were included. Median age was 66 (56-71) years. Twenty-one (46.6%) were admitted to ICU and mortality was 22% (10/45). Compared to HD, a high degree of MT and ID was observed. ICU patients had higher levels of MT, but not of ID, than non-ICU ones. Likewise, patients with BSI had lower EndoCab IgM than non-BSI. Interestingly, patients with high degree of MT and low ID were likely to be admitted to ICU (AUC 0.822). Patients with COVID-19 exhibited high level of MT, especially subjects admitted to ICU. COVID-19 is associated with gut permeability. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8316921/ /pubmed/34335624 http://dx.doi.org/10.3389/fimmu.2021.708149 Text en Copyright © 2021 Oliva, Miele, Di Timoteo, De Angelis, Mauro, Aronica, Al Ismail, Ceccarelli, Pinacchio, d’Ettorre, Mascellino and Mastroianni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Oliva, Alessandra Miele, Maria Claudia Di Timoteo, Federica De Angelis, Massimiliano Mauro, Vera Aronica, Raissa Al Ismail, Dania Ceccarelli, Giancarlo Pinacchio, Claudia d’Ettorre, Gabriella Mascellino, Maria Teresa Mastroianni, Claudio M. Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 |
title | Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 |
title_full | Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 |
title_fullStr | Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 |
title_full_unstemmed | Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 |
title_short | Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19 |
title_sort | persistent systemic microbial translocation and intestinal damage during coronavirus disease-19 |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316921/ https://www.ncbi.nlm.nih.gov/pubmed/34335624 http://dx.doi.org/10.3389/fimmu.2021.708149 |
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