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Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9

Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof(–/–)) mice over the course of 48 weeks. We found otoferlin to be required for proper synapse development in th...

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Detalles Bibliográficos
Autores principales:	Stalmann, Ursula, Franke, Albert Justin, Al-Moyed, Hanan, Strenzke, Nicola, Reisinger, Ellen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316924/ https://www.ncbi.nlm.nih.gov/pubmed/34335185 http://dx.doi.org/10.3389/fncel.2021.677543

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