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Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy
BACKGROUND: Anterior ischemic optic neuropathy (AION) is a group of ophthalmic diseases in which the optic nerve is injured causing blindness. However, the pathogenesis, clinical manifestations, and clinical treatments of AION are yet elusive. Only a few related experimental or clinical reports are...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316943/ https://www.ncbi.nlm.nih.gov/pubmed/34368302 http://dx.doi.org/10.12998/wjcc.v9.i21.5830 |
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author | Zhang, Wei Sun, Xin-Quan Peng, Xiao-Yan |
author_facet | Zhang, Wei Sun, Xin-Quan Peng, Xiao-Yan |
author_sort | Zhang, Wei |
collection | PubMed |
description | BACKGROUND: Anterior ischemic optic neuropathy (AION) is a group of ophthalmic diseases in which the optic nerve is injured causing blindness. However, the pathogenesis, clinical manifestations, and clinical treatments of AION are yet elusive. Only a few related experimental or clinical reports are available on the disease. In this study, spectral domain optical coherence tomography (SD-OCT) was used to examine the morphology of thickness swelling and atrophic changes of macular ganglion cell complex (mGCC) in the different stages of AION that were then compared with the visual fields. Thus, the clinical value of mGCC examination was alleged to be similar to that of the visual field. AIM: To explore the mGCC injury at different stages in AION and the clinical significance. METHODS: Cases with AION were analyzed in a retrospective study. SD-OCT was used to analyze the correlation between mGCC and peripapillary retinal nerve fiber layer thicknesses at different stages of AION and the changes in the corresponding stages of visual fields. RESULTS: A total of 21 cases (28 eyes) presented AION. The onset time of AION was defined as early stage (within 3 wk of onset), middle stage (from 3 wk to 2 mo), and late stage (disease span > 2 mo). In the early stage, the mGCC thickness of SD-OCT was within the normal high limit, and the perioptic nerve fibers thickness was more than the normal. The changes in the visual field in early stage were not consistent with the swelling changes in mGCC and peri-disc nerve fibers. In addition, atrophy and thinning appeared in mGCC, and the perioptic nerve fibers were swollen. However, the thickness was lower in the middle period than that in the early stage. The change in visual field was consistent with that of mGCC in this period. In the late stage, mGCC shrank and thinned, and the thickness of the nerve fibers around the optic disc in the corresponding region shrank and thinned. CONCLUSION: The changes in mGCC thickness in patients with AION showed early, middle, and late stages of development by SD-OCT. Although the early stage visual field changes of AION were not consistent with the swelling changes of mGCC, the horizontal delimitation or annular atrophy of mGCC was consistent with that in the middle and late stage of the disease. The atrophy of peripheral nerve fibers was later than that of the mGCC atrophy. |
format | Online Article Text |
id | pubmed-8316943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-83169432021-08-05 Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy Zhang, Wei Sun, Xin-Quan Peng, Xiao-Yan World J Clin Cases Retrospective Study BACKGROUND: Anterior ischemic optic neuropathy (AION) is a group of ophthalmic diseases in which the optic nerve is injured causing blindness. However, the pathogenesis, clinical manifestations, and clinical treatments of AION are yet elusive. Only a few related experimental or clinical reports are available on the disease. In this study, spectral domain optical coherence tomography (SD-OCT) was used to examine the morphology of thickness swelling and atrophic changes of macular ganglion cell complex (mGCC) in the different stages of AION that were then compared with the visual fields. Thus, the clinical value of mGCC examination was alleged to be similar to that of the visual field. AIM: To explore the mGCC injury at different stages in AION and the clinical significance. METHODS: Cases with AION were analyzed in a retrospective study. SD-OCT was used to analyze the correlation between mGCC and peripapillary retinal nerve fiber layer thicknesses at different stages of AION and the changes in the corresponding stages of visual fields. RESULTS: A total of 21 cases (28 eyes) presented AION. The onset time of AION was defined as early stage (within 3 wk of onset), middle stage (from 3 wk to 2 mo), and late stage (disease span > 2 mo). In the early stage, the mGCC thickness of SD-OCT was within the normal high limit, and the perioptic nerve fibers thickness was more than the normal. The changes in the visual field in early stage were not consistent with the swelling changes in mGCC and peri-disc nerve fibers. In addition, atrophy and thinning appeared in mGCC, and the perioptic nerve fibers were swollen. However, the thickness was lower in the middle period than that in the early stage. The change in visual field was consistent with that of mGCC in this period. In the late stage, mGCC shrank and thinned, and the thickness of the nerve fibers around the optic disc in the corresponding region shrank and thinned. CONCLUSION: The changes in mGCC thickness in patients with AION showed early, middle, and late stages of development by SD-OCT. Although the early stage visual field changes of AION were not consistent with the swelling changes of mGCC, the horizontal delimitation or annular atrophy of mGCC was consistent with that in the middle and late stage of the disease. The atrophy of peripheral nerve fibers was later than that of the mGCC atrophy. Baishideng Publishing Group Inc 2021-07-26 2021-07-26 /pmc/articles/PMC8316943/ /pubmed/34368302 http://dx.doi.org/10.12998/wjcc.v9.i21.5830 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Zhang, Wei Sun, Xin-Quan Peng, Xiao-Yan Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
title | Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
title_full | Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
title_fullStr | Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
title_full_unstemmed | Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
title_short | Macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
title_sort | macular ganglion cell complex injury in different stages of anterior ischemic optic neuropathy |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316943/ https://www.ncbi.nlm.nih.gov/pubmed/34368302 http://dx.doi.org/10.12998/wjcc.v9.i21.5830 |
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