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Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours
BACKGROUND: Tissue acquisition from subepithelial lesions is often attempted by endoscopic ultrasound (EUS)-sampling as conventional endoscopic biopsy usually fails to reach deeper layers of the gastrointestinal wall. AIM: To investigate the utilisation, safety and diagnostic yield of an intensified...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316962/ https://www.ncbi.nlm.nih.gov/pubmed/34368301 http://dx.doi.org/10.12998/wjcc.v9.i21.5822 |
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author | Koutsoumpas, Andreas Perera, Ruwan Melton, Adele Kuker, Jonathan Ghosh, Tilak Braden, Barbara |
author_facet | Koutsoumpas, Andreas Perera, Ruwan Melton, Adele Kuker, Jonathan Ghosh, Tilak Braden, Barbara |
author_sort | Koutsoumpas, Andreas |
collection | PubMed |
description | BACKGROUND: Tissue acquisition from subepithelial lesions is often attempted by endoscopic ultrasound (EUS)-sampling as conventional endoscopic biopsy usually fails to reach deeper layers of the gastrointestinal wall. AIM: To investigate the utilisation, safety and diagnostic yield of an intensified “bite-on-bite” tunnel biopsy technique. METHODS: In this retrospective cohort study, all patients presenting with subepithelial masses in the upper gastrointestinal tract from March 2013 to July 2019 were included. Data were analysed for size and location of the subepithelial mass, use of intensified tunnel biopsy protocol (more than 10 double bite-on-bite biopsies) or superficial conventional biopsies, histology and imaging results, occurrence of readmission and adverse events after endoscopy. RESULTS: Two hundred and twenty-nine patients with subepithelial lesions were included. Superficial conventional biopsies were taken in 117 patients and were diagnostic only in one lipoma (0.9 %). Tunnel biopsies taken in 112/229 (48.9%) patients were significantly more likely to provide histological diagnosis (53.6%; P < 0.001). For lesions ≥ 10mm the diagnostic yield of tunnel biopsies further increased to 41/67 (61.2%). No immediate or delayed complications were reported. Only 8 of the 51 endoscopists (15.7%) regularly attempted tunnel biopsies. CONCLUSION: Tunnel biopsy is a simple, safe and efficient but underutilised diagnostic modality for tissue acquisition in subepithelial masses. It should be routinely attempted at the initial endoscopy. |
format | Online Article Text |
id | pubmed-8316962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-83169622021-08-05 Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours Koutsoumpas, Andreas Perera, Ruwan Melton, Adele Kuker, Jonathan Ghosh, Tilak Braden, Barbara World J Clin Cases Retrospective Cohort Study BACKGROUND: Tissue acquisition from subepithelial lesions is often attempted by endoscopic ultrasound (EUS)-sampling as conventional endoscopic biopsy usually fails to reach deeper layers of the gastrointestinal wall. AIM: To investigate the utilisation, safety and diagnostic yield of an intensified “bite-on-bite” tunnel biopsy technique. METHODS: In this retrospective cohort study, all patients presenting with subepithelial masses in the upper gastrointestinal tract from March 2013 to July 2019 were included. Data were analysed for size and location of the subepithelial mass, use of intensified tunnel biopsy protocol (more than 10 double bite-on-bite biopsies) or superficial conventional biopsies, histology and imaging results, occurrence of readmission and adverse events after endoscopy. RESULTS: Two hundred and twenty-nine patients with subepithelial lesions were included. Superficial conventional biopsies were taken in 117 patients and were diagnostic only in one lipoma (0.9 %). Tunnel biopsies taken in 112/229 (48.9%) patients were significantly more likely to provide histological diagnosis (53.6%; P < 0.001). For lesions ≥ 10mm the diagnostic yield of tunnel biopsies further increased to 41/67 (61.2%). No immediate or delayed complications were reported. Only 8 of the 51 endoscopists (15.7%) regularly attempted tunnel biopsies. CONCLUSION: Tunnel biopsy is a simple, safe and efficient but underutilised diagnostic modality for tissue acquisition in subepithelial masses. It should be routinely attempted at the initial endoscopy. Baishideng Publishing Group Inc 2021-07-26 2021-07-26 /pmc/articles/PMC8316962/ /pubmed/34368301 http://dx.doi.org/10.12998/wjcc.v9.i21.5822 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Cohort Study Koutsoumpas, Andreas Perera, Ruwan Melton, Adele Kuker, Jonathan Ghosh, Tilak Braden, Barbara Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
title | Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
title_full | Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
title_fullStr | Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
title_full_unstemmed | Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
title_short | Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
title_sort | tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours |
topic | Retrospective Cohort Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316962/ https://www.ncbi.nlm.nih.gov/pubmed/34368301 http://dx.doi.org/10.12998/wjcc.v9.i21.5822 |
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