Cargando…

COGENT: evaluating the consistency of gene co-expression networks

SUMMARY: Gene co-expression networks can be constructed in multiple different ways, both in the use of different measures of co-expression, and in the thresholds applied to the calculated co-expression values, from any given dataset. It is often not clear which co-expression network construction met...

Descripción completa

Detalles Bibliográficos
Autores principales: Bozhilova, Lyuba V., Pardo-Diaz, Javier, Reinert, Gesine, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317122/
https://www.ncbi.nlm.nih.gov/pubmed/32931579
http://dx.doi.org/10.1093/bioinformatics/btaa787
Descripción
Sumario:SUMMARY: Gene co-expression networks can be constructed in multiple different ways, both in the use of different measures of co-expression, and in the thresholds applied to the calculated co-expression values, from any given dataset. It is often not clear which co-expression network construction method should be preferred. COGENT provides a set of tools designed to aid the choice of network construction method without the need for any external validation data. AVAILABILITY AND IMPLEMENTATION: https://github.com/lbozhilova/COGENT. SUPPLEMENTARY INFORMATION: Supplementary information is available at Bioinformatics online.