Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds

[Image: see text] Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible intermediates in the 1950s and 1960s. Despite initially being considered mere scientific curiosities, these transient and highly reactive species have now become valuable synthetic building blo...

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Autores principales: Anthony, Sarah M., Wonilowicz, Laura G., McVeigh, Matthew S., Garg, Neil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317162/
https://www.ncbi.nlm.nih.gov/pubmed/34337603
http://dx.doi.org/10.1021/jacsau.1c00214
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author Anthony, Sarah M.
Wonilowicz, Laura G.
McVeigh, Matthew S.
Garg, Neil K.
author_facet Anthony, Sarah M.
Wonilowicz, Laura G.
McVeigh, Matthew S.
Garg, Neil K.
author_sort Anthony, Sarah M.
collection PubMed
description [Image: see text] Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible intermediates in the 1950s and 1960s. Despite initially being considered mere scientific curiosities, these transient and highly reactive species have now become valuable synthetic building blocks. This Perspective highlights recent advances in the field that have allowed access to structural and stereochemical complexity, including recent breakthroughs in asymmetric catalysis.
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spelling pubmed-83171622021-07-28 Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds Anthony, Sarah M. Wonilowicz, Laura G. McVeigh, Matthew S. Garg, Neil K. JACS Au [Image: see text] Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible intermediates in the 1950s and 1960s. Despite initially being considered mere scientific curiosities, these transient and highly reactive species have now become valuable synthetic building blocks. This Perspective highlights recent advances in the field that have allowed access to structural and stereochemical complexity, including recent breakthroughs in asymmetric catalysis. American Chemical Society 2021-06-23 /pmc/articles/PMC8317162/ /pubmed/34337603 http://dx.doi.org/10.1021/jacsau.1c00214 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Anthony, Sarah M.
Wonilowicz, Laura G.
McVeigh, Matthew S.
Garg, Neil K.
Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
title Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
title_full Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
title_fullStr Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
title_full_unstemmed Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
title_short Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
title_sort leveraging fleeting strained intermediates to access complex scaffolds
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317162/
https://www.ncbi.nlm.nih.gov/pubmed/34337603
http://dx.doi.org/10.1021/jacsau.1c00214
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