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The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review

Abuse of methamphetamine (METH), an illicit psychostimulant, is a growing public health issue. METH abuse during pregnancy is on the rise due to its stimulant, anorectic, and hallucinogenic properties. METH can lead to multiple organ toxicity in adults, including neurotoxicity, cardiovascular toxici...

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Autores principales: Li, Jia-Hao, Liu, Jia-Li, Zhang, Kai-Kai, Chen, Li-Jian, Xu, Jing-Tao, Xie, Xiao-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317262/
https://www.ncbi.nlm.nih.gov/pubmed/34335277
http://dx.doi.org/10.3389/fphar.2021.715176
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author Li, Jia-Hao
Liu, Jia-Li
Zhang, Kai-Kai
Chen, Li-Jian
Xu, Jing-Tao
Xie, Xiao-Li
author_facet Li, Jia-Hao
Liu, Jia-Li
Zhang, Kai-Kai
Chen, Li-Jian
Xu, Jing-Tao
Xie, Xiao-Li
author_sort Li, Jia-Hao
collection PubMed
description Abuse of methamphetamine (METH), an illicit psychostimulant, is a growing public health issue. METH abuse during pregnancy is on the rise due to its stimulant, anorectic, and hallucinogenic properties. METH can lead to multiple organ toxicity in adults, including neurotoxicity, cardiovascular toxicity, and hepatotoxicity. It can also cross the placental barrier and have long-lasting effects on the fetus. This review summarizes neurotoxicity, cardiovascular toxicity, hepatotoxicity, toxicity in other organs, and biomonitoring of prenatal METH exposure, as well as the possible emergence of sensitization associated with METH. We proposed the importance of gut microbiota in studying prenatal METH exposure. There is rising evidence of the adverse effects of METH exposure during pregnancy, which are of significant concern.
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spelling pubmed-83172622021-07-29 The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review Li, Jia-Hao Liu, Jia-Li Zhang, Kai-Kai Chen, Li-Jian Xu, Jing-Tao Xie, Xiao-Li Front Pharmacol Pharmacology Abuse of methamphetamine (METH), an illicit psychostimulant, is a growing public health issue. METH abuse during pregnancy is on the rise due to its stimulant, anorectic, and hallucinogenic properties. METH can lead to multiple organ toxicity in adults, including neurotoxicity, cardiovascular toxicity, and hepatotoxicity. It can also cross the placental barrier and have long-lasting effects on the fetus. This review summarizes neurotoxicity, cardiovascular toxicity, hepatotoxicity, toxicity in other organs, and biomonitoring of prenatal METH exposure, as well as the possible emergence of sensitization associated with METH. We proposed the importance of gut microbiota in studying prenatal METH exposure. There is rising evidence of the adverse effects of METH exposure during pregnancy, which are of significant concern. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8317262/ /pubmed/34335277 http://dx.doi.org/10.3389/fphar.2021.715176 Text en Copyright © 2021 Li, Liu, Zhang, Chen, Xu and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Jia-Hao
Liu, Jia-Li
Zhang, Kai-Kai
Chen, Li-Jian
Xu, Jing-Tao
Xie, Xiao-Li
The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
title The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
title_full The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
title_fullStr The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
title_full_unstemmed The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
title_short The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
title_sort adverse effects of prenatal meth exposure on the offspring: a review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317262/
https://www.ncbi.nlm.nih.gov/pubmed/34335277
http://dx.doi.org/10.3389/fphar.2021.715176
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