Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis

BACKGROUND: Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endocytosis of synaptic vesicles in neurons and glutamate over accumulation. Pre...

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Detalles Bibliográficos
Autores principales: Tian, Danfeng, Guo, Yangyang, Zhang, Dandan, Gao, Qiang, Liu, Ganlu, Lin, Jingfeng, Chang, Ze, Wang, Yuchun, Su, Rui, Han, Zhenyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317332/
https://www.ncbi.nlm.nih.gov/pubmed/34321050
http://dx.doi.org/10.1186/s13020-021-00477-4

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