Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability

BACKGROUND: Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of histone H3 on lysine 9 (H3K9me3). Although well studied using artificial chromos...

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Detalles Bibliográficos
Autores principales: Decombe, Sheldon, Loll, François, Caccianini, Laura, Affannoukoué, Kévin, Izeddin, Ignacio, Mozziconacci, Julien, Escudé, Christophe, Lopes, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317386/
https://www.ncbi.nlm.nih.gov/pubmed/34321103
http://dx.doi.org/10.1186/s13072-021-00410-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317386/
https://www.ncbi.nlm.nih.gov/pubmed/34321103
http://dx.doi.org/10.1186/s13072-021-00410-x

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