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Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability
BACKGROUND: Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of histone H3 on lysine 9 (H3K9me3). Although well studied using artificial chromos...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317386/ https://www.ncbi.nlm.nih.gov/pubmed/34321103 http://dx.doi.org/10.1186/s13072-021-00410-x |