Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...

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Detalles Bibliográficos
Autores principales: Ho, Shih-Yin, Lin, Li, Chen, I-Chun, Tsai, Che-Wen, Chang, Fang-Chia, Liou, Horng-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317459/
https://www.ncbi.nlm.nih.gov/pubmed/34335252
http://dx.doi.org/10.3389/fphar.2021.682767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317459/
https://www.ncbi.nlm.nih.gov/pubmed/34335252
http://dx.doi.org/10.3389/fphar.2021.682767

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