Cargando…

Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model

Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a (E1099X/+)). We report here that the PER (2 mg/kg) treatment inhibited the spontaneous recurre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Shih-Yin, Lin, Li, Chen, I-Chun, Tsai, Che-Wen, Chang, Fang-Chia, Liou, Horng-Huei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317459/ https://www.ncbi.nlm.nih.gov/pubmed/34335252 http://dx.doi.org/10.3389/fphar.2021.682767

Ejemplares similares

Long-term Efficacy of Perampanel in a Child with Dravet Syndrome
por: Turón-Viñas, Eulàlia, et al.
Publicado: (2021)

The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome
por: Liu, Shenhai, et al.
Publicado: (2020)

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening
por: Griffin, Aliesha, et al.
Publicado: (2018)

Efficacy and tolerability of perampanel in patients with seizures in real-world clinical practice: A systematic review and meta-analysis
por: Hou, Liyan, et al.
Publicado: (2023)

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a(+/)(-) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome
por: Gu, Feng, et al.
Publicado: (2022)

Fenfluramine: New Treatment for Seizures in Dravet Syndrome
por: Pierce, Joanna Garcia, et al.
Publicado: (2020)

Initial therapeutic target attainment of perampanel in pediatric patients with epilepsy
por: Yu, Lingyan, et al.
Publicado: (2023)

Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome
por: Wong, Jennifer C., et al.
Publicado: (2019)

Acute effect of antiseizure drugs on background oscillations in Scn1a (A1783V) Dravet syndrome mouse model
por: Quinn, Shir, et al.
Publicado: (2023)

Seizure reduction with fluoxetine in an adult woman with Dravet syndrome
por: Meador, Kimford J.
Publicado: (2014)

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model
por: Hawkins, Nicole A., et al.
Publicado: (2017)

Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model
por: Griffin, Aliesha, et al.
Publicado: (2020)

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome
por: Satpute Janve, Vaishali, et al.
Publicado: (2021)

Profile of perampanel and its potential in the treatment of partial onset seizures
por: Rheims, Sylvain, et al.
Publicado: (2013)

Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
por: Dirani, Maya, et al.
Publicado: (2014)

Seizure remission and improvement of neurological function in sialidosis with perampanel therapy
por: Hu, Su-Ching, et al.
Publicado: (2018)

Seizure control in a patient with Dravet syndrome and cystic fibrosis()
por: Schmalbach, Barbara, et al.
Publicado: (2013)

Comparison of the effectiveness and safety of perampanel and oxcarbazepine as monotherapy in children and adolescents with newly diagnosed focal epilepsy
por: Yi, Jia-Qin, et al.
Publicado: (2023)

Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice
por: Moriyama, Hiroshi, et al.
Publicado: (2023)

Sustained seizure remission on perampanel in progressive myoclonic epilepsy (Lafora disease)()
por: Schorlemmer, Kathrin, et al.
Publicado: (2013)

Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy
por: Faulkner, Michele A
Publicado: (2017)

The Effectiveness of Perampanel for Myoclonic Seizures in Down Syndrome with Isodicentric Chromosome 21
por: Obara, Koji, et al.
Publicado: (2020)

Perioperative perampanel administration for early seizure prophylaxis in brain tumor patients
por: Kusakabe, Kosuke, et al.
Publicado: (2023)

Exacerbation of Repetitive Falls Due to Atonic Seizures Following Perampanel Administration
por: Maeda, Akiko, et al.
Publicado: (2023)

Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System
por: De Caro, Carmen, et al.
Publicado: (2021)

Effectiveness of perampanel in the treatment of pediatric patients with focal epilepsy and ESES: A single-center retrospective study
por: Yu, Tao, et al.
Publicado: (2022)

Corrigendum: Comparison of the effectiveness and safety of perampanel and oxcarbazepine as monotherapy in children and adolescents with newly diagnosed focal epilepsy
por: Yi, Jia-Qin, et al.
Publicado: (2023)

Efficacy and safety of adjunctive antiseizure medications for dravet syndrome: A systematic review and network meta-analysis
por: Wu, Jianhua, et al.
Publicado: (2022)

A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication
por: Strzelczyk, Adam, et al.
Publicado: (2022)

Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABA(A) receptors, in a mouse model of Dravet syndrome
por: Nakakubo, Sachiko, et al.
Publicado: (2023)

Investigation of MicroRNA-134 as a Target against Seizures and SUDEP in a Mouse Model of Dravet Syndrome
por: Gerbatin, Rogério R., et al.
Publicado: (2022)

The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome
por: Westenbroek, Ruth, et al.
Publicado: (2023)

Equilibrative Nucleoside Transporters-1 Inhibitors Act as Anti-epileptic Agents by Inhibiting Glutamatergic Transmission
por: Ho, Shih-Yin, et al.
Publicado: (2020)

Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy: A randomized trial
por: French, Jacqueline A., et al.
Publicado: (2015)

Clinical efficacy of perampanel for partial-onset and primary generalized tonic–clonic seizures
por: Besag, Frank MC, et al.
Publicado: (2016)

Cognitive effects of adjunctive perampanel for partial‐onset seizures: A randomized trial
por: Meador, Kimford J., et al.
Publicado: (2016)

ACT-13 RESPONSE TO SEIZURE AND TUMOR-PROGRESSION BY TREATMENT WITH PERAMPANEL IN PATIENTS WITH GLIOMAS
por: Izumoto, Shuichi, et al.
Publicado: (2019)

First add‐on perampanel for focal‐onset seizures: An open‐label, prospective study
por: Kim, Ji Hyun, et al.
Publicado: (2019)

Soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice
por: Hawkins, Nicole A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9gboq3vgnkgmtgfrsrabt3hjle