Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors

Molecular pathogenesis of tumors arising in BRCA1/2 germ-line mutation carriers usually includes somatic inactivation of the remaining allele of the involved gene. Consequently, BRCA1/2-driven cancers are sensitive to platinum-based therapy and poly (ADP-ribose) polymerase inhibitors (PARPi). Long-t...

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Detalles Bibliográficos
Autores principales: Imyanitov, Evgeny, Sokolenko, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317650/
https://www.ncbi.nlm.nih.gov/pubmed/34367927
http://dx.doi.org/10.5306/wjco.v12.i7.544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317650/
https://www.ncbi.nlm.nih.gov/pubmed/34367927
http://dx.doi.org/10.5306/wjco.v12.i7.544

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