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Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate

Primary squamous cell carcinoma is a rare, aggressive disease with historically poor outcomes and no established treatment guidelines. Case reports are limited but describe multiple treatment approaches. Seeking to identify practice patterns and treatment outcomes, we used the US National Cancer Dat...

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Autores principales: Hutten, Ryan J., Weil, Christopher R., Tward, Jonathan D., Lloyd, Shane, Johnson, Skyler B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317810/
https://www.ncbi.nlm.nih.gov/pubmed/34337486
http://dx.doi.org/10.1016/j.euros.2020.11.008
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author Hutten, Ryan J.
Weil, Christopher R.
Tward, Jonathan D.
Lloyd, Shane
Johnson, Skyler B.
author_facet Hutten, Ryan J.
Weil, Christopher R.
Tward, Jonathan D.
Lloyd, Shane
Johnson, Skyler B.
author_sort Hutten, Ryan J.
collection PubMed
description Primary squamous cell carcinoma is a rare, aggressive disease with historically poor outcomes and no established treatment guidelines. Case reports are limited but describe multiple treatment approaches. Seeking to identify practice patterns and treatment outcomes, we used the US National Cancer Data Base to identify 66 males with locoregional primary squamous cell carcinoma of the prostate treated with surgery, chemotherapy, and/or radiotherapy between 2004 and 2015. Patients were stratified into treatment groups consisting of local therapy alone (n = 40; 61%), local therapy and chemotherapy (n = 13; 20%), chemotherapy alone (n = 7; 11%), and observation (n = 6; 9%). Patients with clinical stage T3–T4 disease were significantly more likely to receive combined chemotherapy and local therapy on multivariable analysis. Median survival was 20 mo for patients treated with local therapy alone, 37 mo with local therapy and chemotherapy, and 11 mo with chemotherapy alone. Overall survival was not significantly different between treatment groups. Despite limitations in sample size, these data suggest that addition of chemotherapy to local therapy is a reasonable treatment approach for select patients. PATIENT SUMMARY: Squamous cell carcinoma of the prostate is an extremely rare disease. Our review of patterns of care using data from the National Cancer Data Base shows inconsistent use of combined local and systemic therapy. The small sample size for this rare disease limits any conclusions regarding survival differences, but the data suggest that a combination approach using chemotherapy in addition to surgery or radiation is a reasonable treatment option for disease confined to the prostate.
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spelling pubmed-83178102021-07-29 Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate Hutten, Ryan J. Weil, Christopher R. Tward, Jonathan D. Lloyd, Shane Johnson, Skyler B. Eur Urol Open Sci Brief Correspondence Primary squamous cell carcinoma is a rare, aggressive disease with historically poor outcomes and no established treatment guidelines. Case reports are limited but describe multiple treatment approaches. Seeking to identify practice patterns and treatment outcomes, we used the US National Cancer Data Base to identify 66 males with locoregional primary squamous cell carcinoma of the prostate treated with surgery, chemotherapy, and/or radiotherapy between 2004 and 2015. Patients were stratified into treatment groups consisting of local therapy alone (n = 40; 61%), local therapy and chemotherapy (n = 13; 20%), chemotherapy alone (n = 7; 11%), and observation (n = 6; 9%). Patients with clinical stage T3–T4 disease were significantly more likely to receive combined chemotherapy and local therapy on multivariable analysis. Median survival was 20 mo for patients treated with local therapy alone, 37 mo with local therapy and chemotherapy, and 11 mo with chemotherapy alone. Overall survival was not significantly different between treatment groups. Despite limitations in sample size, these data suggest that addition of chemotherapy to local therapy is a reasonable treatment approach for select patients. PATIENT SUMMARY: Squamous cell carcinoma of the prostate is an extremely rare disease. Our review of patterns of care using data from the National Cancer Data Base shows inconsistent use of combined local and systemic therapy. The small sample size for this rare disease limits any conclusions regarding survival differences, but the data suggest that a combination approach using chemotherapy in addition to surgery or radiation is a reasonable treatment option for disease confined to the prostate. Elsevier 2021-01-03 /pmc/articles/PMC8317810/ /pubmed/34337486 http://dx.doi.org/10.1016/j.euros.2020.11.008 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Correspondence
Hutten, Ryan J.
Weil, Christopher R.
Tward, Jonathan D.
Lloyd, Shane
Johnson, Skyler B.
Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate
title Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate
title_full Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate
title_fullStr Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate
title_full_unstemmed Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate
title_short Patterns of Care and Treatment Outcomes in Locoregional Squamous Cell Carcinoma of the Prostate
title_sort patterns of care and treatment outcomes in locoregional squamous cell carcinoma of the prostate
topic Brief Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317810/
https://www.ncbi.nlm.nih.gov/pubmed/34337486
http://dx.doi.org/10.1016/j.euros.2020.11.008
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