Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy

SARS-CoV-2 is currently causing hundreds of deaths every day in European countries, mostly in not yet vaccinated elderly. Vaccine shortage poses relevant challenges to health authorities, called to act promptly with a scarcity of data. We modeled the mortality reduction of the elderly according to a...

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Autores principales: Pontrelli, Giuseppe, Cimini, Giulio, Roversi, Marco, Gabrielli, Andrea, Salina, Gaetano, Bernardi, Stefania, Rocchi, Francesca, Simonetti, Alessandra, Giaquinto, Carlo, Rossi, Paolo, Sylos Labini, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Public Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318130/
https://www.ncbi.nlm.nih.gov/pubmed/34336771
http://dx.doi.org/10.3389/fpubh.2021.684760
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author Pontrelli, Giuseppe
Cimini, Giulio
Roversi, Marco
Gabrielli, Andrea
Salina, Gaetano
Bernardi, Stefania
Rocchi, Francesca
Simonetti, Alessandra
Giaquinto, Carlo
Rossi, Paolo
Sylos Labini, Francesco
author_facet Pontrelli, Giuseppe
Cimini, Giulio
Roversi, Marco
Gabrielli, Andrea
Salina, Gaetano
Bernardi, Stefania
Rocchi, Francesca
Simonetti, Alessandra
Giaquinto, Carlo
Rossi, Paolo
Sylos Labini, Francesco
author_sort Pontrelli, Giuseppe
collection PubMed
description SARS-CoV-2 is currently causing hundreds of deaths every day in European countries, mostly in not yet vaccinated elderly. Vaccine shortage poses relevant challenges to health authorities, called to act promptly with a scarcity of data. We modeled the mortality reduction of the elderly according to a schedule of mRNA SARS-CoV-2 vaccine that prioritized first dose administration. For the case study of Italy, we show an increase in protected individuals up to 53.4% and a decrease in deaths up to 19.8% in the cohort of over 80's compared with the standard vaccine recalls after 3 or 4 weeks. This model supports the adoption of vaccination campaigns that prioritize the administration of the first doses in the elderly.
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spelling pubmed-83181302021-07-29 Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy Pontrelli, Giuseppe Cimini, Giulio Roversi, Marco Gabrielli, Andrea Salina, Gaetano Bernardi, Stefania Rocchi, Francesca Simonetti, Alessandra Giaquinto, Carlo Rossi, Paolo Sylos Labini, Francesco Front Public Health Public Health SARS-CoV-2 is currently causing hundreds of deaths every day in European countries, mostly in not yet vaccinated elderly. Vaccine shortage poses relevant challenges to health authorities, called to act promptly with a scarcity of data. We modeled the mortality reduction of the elderly according to a schedule of mRNA SARS-CoV-2 vaccine that prioritized first dose administration. For the case study of Italy, we show an increase in protected individuals up to 53.4% and a decrease in deaths up to 19.8% in the cohort of over 80's compared with the standard vaccine recalls after 3 or 4 weeks. This model supports the adoption of vaccination campaigns that prioritize the administration of the first doses in the elderly. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8318130/ /pubmed/34336771 http://dx.doi.org/10.3389/fpubh.2021.684760 Text en Copyright © 2021 Pontrelli, Cimini, Roversi, Gabrielli, Salina, Bernardi, Rocchi, Simonetti, Giaquinto, Rossi and Sylos Labini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Pontrelli, Giuseppe
Cimini, Giulio
Roversi, Marco
Gabrielli, Andrea
Salina, Gaetano
Bernardi, Stefania
Rocchi, Francesca
Simonetti, Alessandra
Giaquinto, Carlo
Rossi, Paolo
Sylos Labini, Francesco
Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy
title Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy
title_full Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy
title_fullStr Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy
title_full_unstemmed Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy
title_short Prioritizing the First Doses of SARS-CoV-2 Vaccine to Save the Elderly: The Case Study of Italy
title_sort prioritizing the first doses of sars-cov-2 vaccine to save the elderly: the case study of italy
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318130/
https://www.ncbi.nlm.nih.gov/pubmed/34336771
http://dx.doi.org/10.3389/fpubh.2021.684760
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