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Characterizing dedifferentiation of thyroid cancer by integrated analysis

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell res...

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Autores principales: Luo, Han, Xia, Xuyang, Kim, Gyeong Dae, Liu, Yang, Xue, Zhinan, Zhang, Lingyun, Shu, Yang, Yang, Tian, Chen, Yan, Zhang, Shouyue, Chen, Haining, Zhang, Weihan, Li, Ruicen, Tang, Huairong, Dong, Birong, Fu, Xianghui, Cheng, Wei, Zhang, Wei, Yang, Li, Peng, Yong, Dai, Lunzhi, Hu, Hongbo, Jiang, Yong, Gong, Changyang, Hu, Yiguo, Zhu, Jingqiang, Li, Zhihui, Caulin, Carlos, Wei, Tao, Park, Jihwan, Xu, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318367/
https://www.ncbi.nlm.nih.gov/pubmed/34321197
http://dx.doi.org/10.1126/sciadv.abf3657
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author Luo, Han
Xia, Xuyang
Kim, Gyeong Dae
Liu, Yang
Xue, Zhinan
Zhang, Lingyun
Shu, Yang
Yang, Tian
Chen, Yan
Zhang, Shouyue
Chen, Haining
Zhang, Weihan
Li, Ruicen
Tang, Huairong
Dong, Birong
Fu, Xianghui
Cheng, Wei
Zhang, Wei
Yang, Li
Peng, Yong
Dai, Lunzhi
Hu, Hongbo
Jiang, Yong
Gong, Changyang
Hu, Yiguo
Zhu, Jingqiang
Li, Zhihui
Caulin, Carlos
Wei, Tao
Park, Jihwan
Xu, Heng
author_facet Luo, Han
Xia, Xuyang
Kim, Gyeong Dae
Liu, Yang
Xue, Zhinan
Zhang, Lingyun
Shu, Yang
Yang, Tian
Chen, Yan
Zhang, Shouyue
Chen, Haining
Zhang, Weihan
Li, Ruicen
Tang, Huairong
Dong, Birong
Fu, Xianghui
Cheng, Wei
Zhang, Wei
Yang, Li
Peng, Yong
Dai, Lunzhi
Hu, Hongbo
Jiang, Yong
Gong, Changyang
Hu, Yiguo
Zhu, Jingqiang
Li, Zhihui
Caulin, Carlos
Wei, Tao
Park, Jihwan
Xu, Heng
author_sort Luo, Han
collection PubMed
description Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Moreover, a potential functional role of CREB3L1 on ATC development was revealed by integrated analyses of copy number alteration and transcriptional regulatory network. Multiple genes in differentiation-related pathways (e.g., EMT) were involved as the downstream targets of CREB3L1, increased expression of which can thus predict higher relapse risk of PTC. Collectively, our study provided insights into the heterogeneity and molecular evolution of thyroid cancer and highlighted the potential driver role of CREB3L1 in its dedifferentiation process.
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spelling pubmed-83183672021-08-10 Characterizing dedifferentiation of thyroid cancer by integrated analysis Luo, Han Xia, Xuyang Kim, Gyeong Dae Liu, Yang Xue, Zhinan Zhang, Lingyun Shu, Yang Yang, Tian Chen, Yan Zhang, Shouyue Chen, Haining Zhang, Weihan Li, Ruicen Tang, Huairong Dong, Birong Fu, Xianghui Cheng, Wei Zhang, Wei Yang, Li Peng, Yong Dai, Lunzhi Hu, Hongbo Jiang, Yong Gong, Changyang Hu, Yiguo Zhu, Jingqiang Li, Zhihui Caulin, Carlos Wei, Tao Park, Jihwan Xu, Heng Sci Adv Research Articles Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Moreover, a potential functional role of CREB3L1 on ATC development was revealed by integrated analyses of copy number alteration and transcriptional regulatory network. Multiple genes in differentiation-related pathways (e.g., EMT) were involved as the downstream targets of CREB3L1, increased expression of which can thus predict higher relapse risk of PTC. Collectively, our study provided insights into the heterogeneity and molecular evolution of thyroid cancer and highlighted the potential driver role of CREB3L1 in its dedifferentiation process. American Association for the Advancement of Science 2021-07-28 /pmc/articles/PMC8318367/ /pubmed/34321197 http://dx.doi.org/10.1126/sciadv.abf3657 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Luo, Han
Xia, Xuyang
Kim, Gyeong Dae
Liu, Yang
Xue, Zhinan
Zhang, Lingyun
Shu, Yang
Yang, Tian
Chen, Yan
Zhang, Shouyue
Chen, Haining
Zhang, Weihan
Li, Ruicen
Tang, Huairong
Dong, Birong
Fu, Xianghui
Cheng, Wei
Zhang, Wei
Yang, Li
Peng, Yong
Dai, Lunzhi
Hu, Hongbo
Jiang, Yong
Gong, Changyang
Hu, Yiguo
Zhu, Jingqiang
Li, Zhihui
Caulin, Carlos
Wei, Tao
Park, Jihwan
Xu, Heng
Characterizing dedifferentiation of thyroid cancer by integrated analysis
title Characterizing dedifferentiation of thyroid cancer by integrated analysis
title_full Characterizing dedifferentiation of thyroid cancer by integrated analysis
title_fullStr Characterizing dedifferentiation of thyroid cancer by integrated analysis
title_full_unstemmed Characterizing dedifferentiation of thyroid cancer by integrated analysis
title_short Characterizing dedifferentiation of thyroid cancer by integrated analysis
title_sort characterizing dedifferentiation of thyroid cancer by integrated analysis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318367/
https://www.ncbi.nlm.nih.gov/pubmed/34321197
http://dx.doi.org/10.1126/sciadv.abf3657
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