Regulation of telomere homeostasis and genomic stability in cancer by N(6)-adenosine methylation (m(6)A)

The role of RNA methylation on N(6)-adenosine (m(6)A) in cancer has been acknowledged, but the underlying mechanisms remain obscure. Here, we identified homeobox containing 1 (HMBOX1) as an authentic target mRNA of m(6)A machinery, which is highly methylated in malignant cells compared to the normal...

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Detalles Bibliográficos
Autores principales: Lee, Ji Hoon, Hong, Juyeong, Zhang, Zhao, de la Peña Avalos, Bárbara, Proietti, Cecilia J., Deamicis, Agustina Roldán, Guzmán G., Pablo, Lam, Hung-Ming, Garcia, Jose, Roudier, Martine P., Sisk, Anthony E., De La Rosa, Richard, Vu, Kevin, Yang, Mei, Liao, Yiji, Scheirer, Jessica, Pechacek, Douglas, Yadav, Pooja, Rao, Manjeet K., Zheng, Siyuan, Johnson-Pais, Teresa L., Leach, Robin J., Elizalde, Patricia V., Dray, Eloïse, Xu, Kexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318370/
https://www.ncbi.nlm.nih.gov/pubmed/34321211
http://dx.doi.org/10.1126/sciadv.abg7073

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