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Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities
Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of joint degeneration by a progressive decline in th...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318388/ https://www.ncbi.nlm.nih.gov/pubmed/34336816 http://dx.doi.org/10.3389/fcell.2021.625497 |
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author | Ramasamy, Thamil Selvee Yee, Yong Mei Khan, Ilyas M. |
author_facet | Ramasamy, Thamil Selvee Yee, Yong Mei Khan, Ilyas M. |
author_sort | Ramasamy, Thamil Selvee |
collection | PubMed |
description | Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of joint degeneration by a progressive decline in the homeostatic and regenerative capacity of cells. Cellular aging is the manifestation of a complex interplay of cellular and molecular pathways underpinned by transcriptional, translational, and epigenetic mechanisms and niche factors, and unraveling this complexity will improve our understanding of underlying molecular changes that affect the ability of the articular cartilage to maintain or regenerate itself. This insight is imperative for developing new cell and drug therapies for OA disease that will target the specific causes of age-related functional decline. This review explores the key age-related changes within articular chondrocytes and discusses the molecular mechanisms that are commonly perturbed as cartilage ages and degenerates. Current efforts and emerging potential therapies in treating OA that are being employed to halt or decelerate the aging processes are also discussed. |
format | Online Article Text |
id | pubmed-8318388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83183882021-07-29 Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities Ramasamy, Thamil Selvee Yee, Yong Mei Khan, Ilyas M. Front Cell Dev Biol Cell and Developmental Biology Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of joint degeneration by a progressive decline in the homeostatic and regenerative capacity of cells. Cellular aging is the manifestation of a complex interplay of cellular and molecular pathways underpinned by transcriptional, translational, and epigenetic mechanisms and niche factors, and unraveling this complexity will improve our understanding of underlying molecular changes that affect the ability of the articular cartilage to maintain or regenerate itself. This insight is imperative for developing new cell and drug therapies for OA disease that will target the specific causes of age-related functional decline. This review explores the key age-related changes within articular chondrocytes and discusses the molecular mechanisms that are commonly perturbed as cartilage ages and degenerates. Current efforts and emerging potential therapies in treating OA that are being employed to halt or decelerate the aging processes are also discussed. Frontiers Media S.A. 2021-07-14 /pmc/articles/PMC8318388/ /pubmed/34336816 http://dx.doi.org/10.3389/fcell.2021.625497 Text en Copyright © 2021 Ramasamy, Yee and Khan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Ramasamy, Thamil Selvee Yee, Yong Mei Khan, Ilyas M. Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
title | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
title_full | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
title_fullStr | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
title_full_unstemmed | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
title_short | Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities |
title_sort | chondrocyte aging: the molecular determinants and therapeutic opportunities |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318388/ https://www.ncbi.nlm.nih.gov/pubmed/34336816 http://dx.doi.org/10.3389/fcell.2021.625497 |
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