Structure-guided microbial targeting of antistaphylococcal prodrugs

Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydroly...

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Detalles Bibliográficos
Autores principales: Miller, Justin J, Shah, Ishaan T, Hatten, Jayda, Barekatain, Yasaman, Mueller, Elizabeth A, Moustafa, Ahmed M, Edwards, Rachel L, Dowd, Cynthia S, Hoops, Geoffrey C, Johnson, R Jeremy, Planet, Paul J, Muller, Florian L, Jez, Joseph M, Odom John, Audrey R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318587/
https://www.ncbi.nlm.nih.gov/pubmed/34279224
http://dx.doi.org/10.7554/eLife.66657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318587/
https://www.ncbi.nlm.nih.gov/pubmed/34279224
http://dx.doi.org/10.7554/eLife.66657

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